DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and bche

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_002931610.1	Gene:	bche / 100495889	XenbaseID:	XB-GENE-980117	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	578	Identity:	150/578 - (25%)
Similarity:	253/578 - (43%)	Gaps:	101/578 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ETCELTLPVGQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKP 73
            ||..:....|::.|| ::|::.....:|..||:|:||:|:|||:.|||..|||.:.:.:.|....
Frog    29 ETDIVDTKYGKVTGV-QISVFSGIITAFLGIPYAEPPIGDLRFKKPVPHKPWSEIWNASQYGNSC 92

  Fly    74 TQR------GLLTREI-----EGGEDCLYLNVYSKQLKSEKP--LPVMVYIYGGAFTVGEATREL 125
            .|.      |....|:     :..|||||||::   :.:.||  ..|||:||||:|..|.::.:|
Frog    93 YQTVDQIFPGFSGAEMWNPNTQLSEDCLYLNIW---IPTPKPRNASVMVWIYGGSFETGTSSLDL 154

  Fly   126 Y-GPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSN 189
            | |.....|:.|::|::|||:..||||:....: :.|||.||.||.|||:||.:.|:.|.|:..:
Frog   155 YDGKFLARTERVIVVSMNYRLGALGFLAFPGNN-EAPGNVGLFDQRLALQWVYENIAAFGGNPKS 218

  Fly   190 ITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWA---NNPAEDFAFRLAQ-QNGFTGE 250
            ||:|||||||.|..:.|.:.::.|.|.:||..|.|.:..||   ...|.:.|..||. .|.|  .
Frog   219 ITIFGESAGGASVSYHMLSPKSHGFFTRAIMQSATANAPWAVITKAEASNRALTLANLLNCF--Y 281

  Fly   251 NDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSN 315
            .::.:::..|:.....::....:....| |:.:...|.|||:.    |.::..|.:.|.......
Frog   282 RNETEIIACLRNKSPEEIFEKAVSVLPH-RSVIEVNFPPTVDG----DFLIEMPEILMQLGQLKK 341

  Fly   316 NFPVMLGGTSFEG----LFMYPAVSANLKALDSLSQ----------DPTRLVPVDV---RTVSSE 363
            ...::.|....||    ::..|..|.:.::..:.:|          ..|.|....|   .|...:
Frog   342 KTQILTGVNKDEGSYFLVYGLPGFSKDHESFINRTQFHKSVKLAFPKATELAIDSVLFHYTNWED 406

  Fly   364 KENLEYSQRLMKAYFG----------YSPPSSELLLNMLDFY----SYKIFWHGFNRTFNARLTY 414
            ::|..:::..|....|          ::..:|||..|...:|    |.|:.|.|:
Frog   407 EQNPSHNRDAMDDIVGDYNFICPLLEFTKWNSELGNNAYLYYFHHRSSKLTWPGW---------- 461

  Fly   415 AKAPTYYYRFDFDSPNFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMI 479
                                          .||.|..::.::|......:|:.|.||......::
Frog   462 ------------------------------MGVMHGYEIEFVFGIPMYRRLNYTKAEETLSRTLM 496

  Fly   480 GIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYEKLQIWDNLY 537
            ..|..||.|.|||..:.....|...|.::...::..:.|.........::.:.|:|.|
Frog   497 RYWANFAKTGNPNGAQSSENRWPVFTLDEQHYLMLGTEDSKTNRKMRAKQCRFWNNFY 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	146/549 (27%)
bche	XP_002931610.1	COesterase	32..550	CDD:365897	145/569 (25%)
bche	XP_002931610.1	AChE_tetra	565..599	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910