DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and ache

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_002940088.1	Gene:	ache / 100490673	XenbaseID:	XB-GENE-923160	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	578	Identity:	154/578 - (26%)
Similarity:	245/578 - (42%)	Gaps:	109/578 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKR--LSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQ----- 75
            |:::|:::  ||.:   ..:|..||||:||:.::|||...|..||:.|.|.|.|.....|
Frog    36 GKVRGLRQPVLSTH---VSAFLGIPFAEPPVDKMRFRRSEPKKPWTDVWDATAYPNACYQYFDTL 97

  Fly    76 -RGLLTREIEG-----GEDCLYLNVYSKQLKSEKPLP----VMVYIYGGAFTVGEATRELYGPDY 130
             .|....|:..     .|||||||::...     |.|    |||:||||.|..|.::.::|...|
Frog    98 YPGFPGMEMWNPNRPMSEDCLYLNIWVPH-----PRPSNATVMVWIYGGGFYSGSSSLDVYDGRY 157

  Fly   131 FM-TKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFG 194
            .. .::|::|::||||...|||:|...|:..|||.||.||.|||:||:..|:.|.||...:|:||
Frog   158 LCHAENVIVVSMNYRVGAFGFLTLTPGSVDAPGNVGLFDQRLALQWVQDNIAFFGGDPRTVTIFG 222

  Fly   195 ESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQNGFTG--ENDDAKVL 257
            ||||..|....:.:..:..||.||...||:.:..||....::...|......|..  ..:|.::|
Frog   223 ESAGAVSVGMHVLSPGSHHLFSKAALQSGSPNTPWATITPQEARRRTELLGKFLDCRMGNDTELL 287

  Fly   258 EYLQGVPARDLVNHN---LLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPV 319
            ..|:....::|::|.   |..|...|    |||.|..:|     ...|:||..:.........|:
Frog   288 NCLRVKQPQELIDHEFSVLPAPSVFR----FAFVPVPDA-----DFFPEPPEILMNMGRFKPCPL 343

  Fly   320 MLGGTSFEG----LFMYPAVSANLKAL-----------------DSLSQDPTRLVPVDVRTVSSE 363
            ::|....||    |:..|..|.|.::|                 :.::.:...:...|.....:.
Frog   344 IMGVNQNEGSYFLLYGAPGFSKNNESLITREEFLGGVKMSVPQANDIALEAVVMQYTDWADEHAG 408

  Fly   364 KENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFDFDS 428
            .:|.|...:|:..:....|         |.:::.|:...| ||            .|.|.||..:
Frog   409 VKNREAMDQLVGDHNVICP---------LTYFAGKVAETG-NR------------VYTYFFDHRA 451

  Fly   429 PNFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATSNPNC 493
            .|..:.:        ..||.|..::.::|.......|:.|..|.....||:..|..||.|.:||.
Frog   452 SNLAWPQ--------WMGVPHGYEIEFVFGLPLDANLNYTPQEEALSRRMMRYWANFARTGDPNE 508

  Fly   494 PEIGHL-EWKPSTKNDPKRVINISSDVTIIDLPEYEKLQ--------IWDNLYKPNQL 542
            ....|. .|...|.::.:.:        .::...|::||        .| |.:.|..|
Frog   509 GNDAHQPRWPLYTASEQRYM--------ALNNKPYQELQGIRVQTCMFW-NRFLPKLL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	147/536 (27%)
ache	XP_002940088.1	COesterase	31..549	CDD:395084	150/567 (26%)
ache	XP_002940088.1	AChE_tetra	564..597	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910