DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and LOC100334697

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_002661384.2	Gene:	LOC100334697 / 100334697	-ID:	-	Length:	576	Species:	Danio rerio

Alignment Length:	569	Identity:	154/569 - (27%)
Similarity:	242/569 - (42%)	Gaps:	129/569 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ELTLPVGQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQR 76
            :|.:..|.::|:    |.|..|. |..||||.||:|..|::||.|..||.||.|.:.      .|
Zfish    51 KLLIKDGLVQGL----LLDKSYV-FYGIPFADPPVGTSRWKAPRPVTPWKGVYDASF------PR 104

  Fly    77 GLLTREIEG----------GEDCLYLNVY---SKQLKSE--KPLPVMVYIYGGAFTVGEATRELY 126
            ....:...|          .||||||||:   |..|.:.  :|||||::|:||.|..|.|::.||
Zfish   105 AACMQACIGPIADDCPKKVSEDCLYLNVFVPLSVDLATPLLQPLPVMLWIHGGDFIAGSASKPLY 169

  Fly   127 G----PDYFMTKDVVLVTLNYRVDCLGFL-SLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGD 186
            .    .:|..|   |:|::.||:...||| |.|||.....||.|:.||..||.||:|.|:.|.||
Zfish   170 DGRFISNYTQT---VIVSIAYRLGAFGFLVSGKDPKSTAVGNYGILDQQAALIWVQQNIAAFGGD 231

  Fly   187 DSNITVFGESAGGCSTHFMMCTEQTRGLFHKAI----PMS------------GTVHNYWANNPAE 235
            .|.:|:||||||..|....:..:.::.||.:|:    |.|            |......||...|
Zfish   232 PSRVTIFGESAGAQSVSLHLMIQSSKPLFKQAVFQSLPFSIPLKTRRESLKLGKHFAKAANCSLE 296

  Fly   236 DFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGLLF-----AFGPTVEAYV 295
            |                    ::.||.:.|.|:::..:.|.....|...|     .:||.::..:
Zfish   297 D--------------------MKCLQSLSAEDVLHAQIKTSSKLVNPFRFLEVFEIWGPFIDGEL 341

  Fly   296 GEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEG-LFMYPAVSANLKALDSLSQDPTRLVPVDVRT 359
            .::..|.    ...:..|....||:||.||.|| :|:|           .:.:.|...|...:.|
Zfish   342 IKEQAVS----AFQKGHWQKEKPVLLGTTSEEGVIFVY-----------GVFKKPVSAVECTIYT 391

  Fly   360 VSSEKENLEYSQRLMKAYFG-YSPPS-SELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYY 422
            .:..|   :::.::::.|.. ||... .::|..::..|   |||....|:..|.: .:.:..:.|
Zfish   392 TAIFK---QHAIKILRKYLPLYSDADRRDMLAQIVTDY---IFWCPSRRSARAAV-LSGSSAWMY 449

  Fly   423 RFDFDSPNFNFYRAKFCGDKIKTGVA-------HADDLSYLFRNAGSWKLDKTSAEYRTIERMIG 480
            .||..|.:          .::.:||:       |..:|.::|.:|.......|.||.....|::.
Zfish   450 VFDQVSSD----------PRVWSGVSSCYQRVCHGAELPFVFDSASVANFSMTPAEKLLSNRVLC 504

  Fly   481 IWTAFAATSNPN------------CPEIGHLEWKPSTKNDPKRVINISS 517
            .|..||.|.||.            |.:.....|...|.|....::|:::
Zfish   505 YWGGFAHTGNPTGETRRPSDISGFCRQQRPPSWPSYTANRGWMIMNLTA 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	153/560 (27%)
LOC100334697	XP_002661384.2	COesterase	44..569	CDD:278561	154/569 (27%)
LOC100334697	XP_002661384.2	Aes	<138..>245	CDD:223730	49/109 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940