DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and Ces1f

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	176/600 - (29%)
Similarity:	260/600 - (43%)	Gaps:	121/600 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SLETCEL-----TLPV-----GQIKGVKRLSL--YDDPYFSFEKIPFAKPPLGELRFRAPVPADP 59
            ||.||.:     :.||     |::.| |.:||  .......|..:||||||||.|||..|.||:|
  Rat    10 SLATCVVYGNPSSPPVVDTTKGKVLG-KYVSLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEP 73

  Fly    60 WSGVLDCTHY--------AEKPTQRGLLTR-----EIEGGEDCLYLNVYS-KQLKSEKPLPVMVY 110
            ||.|.:.|.|        |:......|||.     .:|..|||||||:|: ........|||||:
  Rat    74 WSFVKNTTTYPPMCSQDAAKGQRMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKNSRLPVMVW 138

  Fly   111 IYGGAFTVGEATRELY-GPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALK 174
            |:||..|:|.|:  .| |......::||:|.:.||:...||.|..|...:  ||.|..|||.||.
  Rat   139 IHGGGMTLGGAS--TYDGRVLSAYENVVVVAIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALH 199

  Fly   175 WVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDF-- 237
            ||:..|:||.||..::|:|||||||.|...::.:..|:.|||:||..||.|  :......:|.
  Rat   200 WVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLTKNLFHRAISESGVV--FLPGLLTKDVRP 262

  Fly   238 -AFRLAQQNGFTGENDDAKVLEYLQGVPARDLV----NHNLLTPEHRRNGLLFAFGPTVEAY--- 294
             |.::|...| ......|.::..|:.....:|:    ..||:....:|:        ..|:|
  Rat   263 AAKQIADMAG-CETTTSAIIVHCLRQKTEEELLEIMKKMNLIKLSSQRD--------NKESYHFL 318

  Fly   295 --VGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPA--------VSANLKALDSLSQDP 349
              |.::.|:||.|.|:..:...|..|.::|....|..::.|.        |..:.|...:|.:..
  Rat   319 STVVDNVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMGFVPADVELDKKMAITLLEKF 383

  Fly   350 TRL--VPVDVRTVSSEK------ENLEYSQRLMKAYFG---YSPPSSELLLNMLDFYSYKIFWHG 403
            ..|  :|.|:..|:.||      ::::....:: |:.|   :|.||..:..:..|
  Rat   384 ASLYGIPEDIIPVAIEKYRKGSDDSIKIRDGIL-AFIGDVSFSIPSVMVSRDHRD---------- 437

  Fly   404 FNRTFNARLTYAKAPTYYYRF----DFDSPNFNFYRAK-FCGDKIKTGVAHADDLSYLFRNAGSW 463
                       |.||||.|.:    .|.||.    |.| ..||       |||||..:|   |:.
  Rat   438 -----------AGAPTYMYEYQYYPSFSSPQ----RPKHVVGD-------HADDLYSVF---GAP 477

  Fly   464 KL-DKTSAEYRTIERMI-GIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPE 526
            .| |..|.|...:.:|: ..|..||...|||...:.|  |....:.:  ..:.|.:........:
  Rat   478 ILRDGASEEEIKLSKMVMKFWANFARNGNPNGRGLPH--WPQYDQKE--EYLQIGATTQQSQRLK 538

  Fly   527 YEKLQIWDNLYKPNQ 541
            .|::..|..|....|
  Rat   539 AEEVAFWTQLLAKRQ 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	171/567 (30%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	169/576 (29%)
		Aes	<121..>234	CDD:223730	47/116 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336525
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650