DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est5 and Ces1f

DIOPT Version :10

Sequence 1:NP_001246965.1 Gene:alpha-Est5 / 40905 FlyBaseID:FBgn0261393 Length:543 Species:Drosophila melanogaster
Sequence 2:NP_001096829.2 Gene:Ces1f / 100125372 RGDID:1642419 Length:561 Species:Rattus norvegicus


Alignment Length:600 Identity:176/600 - (29%)
Similarity:260/600 - (43%) Gaps:121/600 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SLETCEL-----TLPV-----GQIKGVKRLSL--YDDPYFSFEKIPFAKPPLGELRFRAPVPADP 59
            ||.||.:     :.||     |::.| |.:||  .......|..:||||||||.|||..|.||:|
  Rat    10 SLATCVVYGNPSSPPVVDTTKGKVLG-KYVSLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEP 73

  Fly    60 WSGVLDCTHY--------AEKPTQRGLLTR-----EIEGGEDCLYLNVYS-KQLKSEKPLPVMVY 110
            ||.|.:.|.|        |:......|||.     .:|..|||||||:|: ........|||||:
  Rat    74 WSFVKNTTTYPPMCSQDAAKGQRMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKNSRLPVMVW 138

  Fly   111 IYGGAFTVGEATRELY-GPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALK 174
            |:||..|:|.|:  .| |......::||:|.:.||:...||.|..|...:  ||.|..|||.||.
  Rat   139 IHGGGMTLGGAS--TYDGRVLSAYENVVVVAIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALH 199

  Fly   175 WVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDF-- 237
            ||:..|:||.||..::|:|||||||.|...::.:..|:.|||:||..||.|  :......:|.  
  Rat   200 WVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLTKNLFHRAISESGVV--FLPGLLTKDVRP 262

  Fly   238 -AFRLAQQNGFTGENDDAKVLEYLQGVPARDLV----NHNLLTPEHRRNGLLFAFGPTVEAY--- 294
             |.::|...| ......|.::..|:.....:|:    ..||:....:|:        ..|:|   
  Rat   263 AAKQIADMAG-CETTTSAIIVHCLRQKTEEELLEIMKKMNLIKLSSQRD--------NKESYHFL 318

  Fly   295 --VGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPA--------VSANLKALDSLSQDP 349
              |.::.|:||.|.|:..:...|..|.::|....|..::.|.        |..:.|...:|.:..
  Rat   319 STVVDNVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMGFVPADVELDKKMAITLLEKF 383

  Fly   350 TRL--VPVDVRTVSSEK------ENLEYSQRLMKAYFG---YSPPSSELLLNMLDFYSYKIFWHG 403
            ..|  :|.|:..|:.||      ::::....:: |:.|   :|.||..:..:..|          
  Rat   384 ASLYGIPEDIIPVAIEKYRKGSDDSIKIRDGIL-AFIGDVSFSIPSVMVSRDHRD---------- 437

  Fly   404 FNRTFNARLTYAKAPTYYYRF----DFDSPNFNFYRAK-FCGDKIKTGVAHADDLSYLFRNAGSW 463
                       |.||||.|.:    .|.||.    |.| ..||       |||||..:|   |:.
  Rat   438 -----------AGAPTYMYEYQYYPSFSSPQ----RPKHVVGD-------HADDLYSVF---GAP 477

  Fly   464 KL-DKTSAEYRTIERMI-GIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPE 526
            .| |..|.|...:.:|: ..|..||...|||...:.|  |....:.:  ..:.|.:........:
  Rat   478 ILRDGASEEEIKLSKMVMKFWANFARNGNPNGRGLPH--WPQYDQKE--EYLQIGATTQQSQRLK 538

  Fly   527 YEKLQIWDNLYKPNQ 541
            .|::..|..|....|
  Rat   539 AEEVAFWTQLLAKRQ 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est5NP_001246965.1 alpha/beta hydrolases 12..533 CDD:473884 169/585 (29%)
Ces1fNP_001096829.2 COesterase 22..545 CDD:395084 169/578 (29%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 558..561
Blue background indicates that the domain is not in the aligned region.

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