Protein Alignment alphaTub84D and TUBB3

DIOPT Version :10

• Sequence 1: NP_524264.1
• Gene: alphaTub84D / 40904
• FlyBaseID: FBgn0003885
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_006077.2
• Gene: TUBB3 / 10381
• HGNCID: 20772
• Length: 450
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 182/452 - (40%)
• Similarity: 272/452 - (60%)
• Gaps: 16/452 - (3%)

  Fly     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGD---DSFNTFFSETGAGKHV 62
            |||.:.|..||.|.|||...||:...||||.|.|..     ||..|   :..:.:::|..:.|:|
Human     1 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNY-----VGDSDLQLERISVYYNEASSHKYV 60

  Fly    63 PRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLAD 127
            |||:.|||||..:|.||:|.:..||.|:..|.|:..|.||:|:||||.|.|:||.|||.:||..:
Human    61 PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECE 125

  Fly   128 QCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAVYPAPQVSTAVVEPYNSILTTH 192
            .|..||||.:.||.|||||||..:||:.::..:|..:....|:|.|:|:||..||||||:.|:.|
Human   126 NCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIH 190

  Fly   193 TTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQT 257
            ..:|::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|.||||.|.||.||.:...
Human   191 QLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAV 255

  Fly   258 NLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKVDPRHGKYMACCMLYRGD 322
            |:||:||:||.:..:||:.:.....:..|:|.|:|...|:..|.|...|||||:|:....::||.
Human   256 NMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGR 320

  Fly   323 VVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEA 387
            :..|:|:..:..|::|.:..||:|.|...||.:...||        ..::.:...:.|:|||.|.
Human   321 MSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPP--------RGLKMSSTFIGNSTAIQEL 377

  Fly   388 WARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGDGEGEGAEE 449
            :.|:..:|..|:.::||:|||.||||:|.||:||..::..|..:|::....:.:.|||..|:
Human   378 FKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYED 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub84D	NP_524264.1	PTZ00335	1..439	CDD:185562	178/440 (40%)
TUBB3	NP_006077.2	PLN00220	1..447	CDD:215107	182/452 (40%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..450		4/15 (27%)