DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rtnl2 and RTN2

DIOPT Version :9

Sequence 1:	NP_001246964.1	Gene:	Rtnl2 / 40903	FlyBaseID:	FBgn0015831	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_005610.1	Gene:	RTN2 / 6253	HGNCID:	10468	Length:	545	Species:	Homo sapiens

Alignment Length:	158	Identity:	46/158 - (29%)
Similarity:	86/158 - (54%)	Gaps:	1/158 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NLLLWRNSRKTLIVFTGILLLLLDVMVHSVISVISMVGITVLIAAIGHRLLVQFWSIWKKDENKD 85
            :||.|:::|.:.:||||:::.||.::..|::||.:.:.:.:|...|..|:..:......:.:..:
Human   347 DLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGAN 411

  Fly    86 QILRFYPHPKIEIPREETLYLAGKAVSHINLILNRMIELLLVEKWEDSLKFLVLLCGINLLGDCF 150
            . .:.|....:.:.||:|..|:.:..|.:.....::....|||...||||..:|...:..:|..|
Human   412 P-FQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIF 475

  Fly   151 NGLTLLIFGHLFIFTVPKLYESYKPFVD 178
            |||||||.|.:.:||:|.||..::..:|
Human   476 NGLTLLILGVIGLFTIPLLYRQHQAQID 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl2	NP_001246964.1	Reticulon	21..183	CDD:280592	46/158 (29%)
RTN2	NP_005610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..183
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..250
		Reticulon	345..509	CDD:280592	46/158 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.700