DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rtnl2 and ret-1

DIOPT Version :9

Sequence 1:	NP_001246964.1	Gene:	Rtnl2 / 40903	FlyBaseID:	FBgn0015831	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_001123026.1	Gene:	ret-1 / 179981	WormBaseID:	WBGene00004336	Length:	3303	Species:	Caenorhabditis elegans

Alignment Length:	184	Identity:	56/184 - (30%)
Similarity:	97/184 - (52%)	Gaps:	20/184 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KDSSQIFMDLK-------NLLLWRNSRKTLIVFTGILLLLLDVMVHSVISVISMVGITVLIAAIG 67
            |.....::|.|       :::.||:::|:.||.:..||:|..:..:.:::|::...:..|.||.|
Worm  3088 KHHGDAWIDFKTVPPCVLDVIYWRDAKKSAIVLSLALLVLFVLAKYPLLTVVTYSLLLALGAAAG 3152

  Fly    68 HRLLVQFWSIWKKDENKDQILRF-YPHPKIEI-------PREETLYLAGKAVSHINLILNRMIEL 124
            .|   ..:|::||.|  .||.:. ..||..||       |:|:....|...|.|...|.|::.:|
Worm  3153 FR---SIFSVFKKVE--AQIKKTDSEHPFSEILAQDLTLPQEKVHAQADVFVEHATCIANKLKKL 3212

  Fly   125 LLVEKWEDSLKFLVLLCGINLLGDCFNGLTLLIFGHLFIFTVPKLYESYKPFVD 178
            :.||...:|:||.::|..:..:...|:|.||.|.|.|.:|:|||:|||.:..:|
Worm  3213 VFVESPLESIKFGLVLWSLTYIASWFSGFTLAILGLLGVFSVPKVYESNQEAID 3266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl2	NP_001246964.1	Reticulon	21..183	CDD:280592	53/166 (32%)
ret-1	NP_001123026.1	PRK01558	<2835..>2918	CDD:304934
ret-1	NP_001123026.1	Reticulon	3104..3272	CDD:280592	53/168 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840