DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Ache

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_038945765.1	Gene:	Ache / 83817	RGDID:	69313	Length:	616	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	181/590 - (30%)
Similarity:	270/590 - (45%)	Gaps:	78/590 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FLILRCCPGFKRFSCQSAGDADSK-VVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARF 81
            ||:|....|    ..::.|..|.: :|::..|.::|.||.. .|....:|.|||||:||:|..||
  Rat    19 FLLLSLLGG----GARAEGREDPQLLVRVRGGQLRGIRLKA-PGGPVSAFLGIPFAEPPVGSRRF 78

  Fly    82 VASQLADPWNSELDARQERPIPLQ-MDRRSGKVVG----------SEDCLYLNVYTKHFNESEPP 135
            :..:...||:..|||...:.:..| :|.......|          |||||||||:|. :.....|
  Rat    79 MPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTP-YPRPTSP 142

  Fly   136 LPVMVYIYGGAFRTGGAVKSKYGPDYLMS-RDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHD 199
            .||:::||||.|.:|.:....|...:|.. ...|.|..|||:.:.|||::| |..|.|||.||.|
  Rat   143 TPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALP-GSRDAPGNVGLLD 206

  Fly   200 QLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHF-MMCLPQAKGLFHKAIMMSGSMLSPWVNA 263
            |.||||||.::|..|.|||.::||||||||||||.. ::.|| ::.|||:|::.||:...||...
  Rat   207 QRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLP-SRSLFHRAVLQSGTPNGPWATV 270

  Fly   264 PDSDG-----IFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDF-ISPRDRCFGFLNPFAPV 322
            ...:.     :..||...........:..::..||...|:.|:.|:: :.|::..|.|  .|.||
  Rat   271 SAGEARRRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRF--SFVPV 333

  Fly   323 VGG--LVAAPFQQLMKEAWSCEVPLLLGGTSFEG---LVY-YPFCQLDNGYMLELLKHEPAMVLP 381
            |.|  |...| :.|:......::.:|:|....||   ||| .|....||..::...:....:
  Rat   334 VDGDFLSDTP-EALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGV--- 394

  Fly   382 HELYQSMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVV------LSRLS 440
                 .:.|.:.:..|...|..|| ...:...:...:.|..|..:   |.|.||      ..||:
  Rat   395 -----RIGVPQASDLAAEAVVLHY-TDWLHPEDPAHLRDAMSAVV---GDHNVVCPVAQLAGRLA 450

  Fly   441 HAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQPLDS------PEF 499
            ...|..|.|.|:..:..|..        .:..||.|..::.:||      ..|||.      .|.
  Rat   451 AQGARVYAYIFEHRASTLTW--------PLWMGVPHGYEIEFIF------GLPLDPSLNYTVEER 501

  Fly   500 LTIQRMVGILTTFARTGDPNCPETGPDP-WMPVSTKS-PFKALNIGQQVECVTQVEKDGLKVWNR 562
            :..||::...|.||||||||.|.....| |.|.:|.: .:.:||: :.:|....:.......|||
  Rat   502 IFAQRLMKYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNL-KPLEVRRGLRAQTCAFWNR 565

  Fly   563 LYSDL 567
            ....|
  Rat   566 FLPKL 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	169/537 (31%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	76/199 (38%)
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	171/559 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910