Protein Alignment alpha-Est6 and TG

DIOPT Version :10

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_003226.4
• Gene: TG / 7038
• HGNCID: 11764
• Length: 2768
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 153/622 - (24%)
• Similarity: 237/622 - (38%)
• Gaps: 160/622 - (25%)

  Fly    25 PGFKRFSCQSAGDADSKVVKLSV-GSVKGRRLS---GIYGDEFYSFEGIPFAKPPLGKARFVASQ 85
            ||....|.    :|....|.:|. |.:.||..:   |....:...|.|:|:|.|||.:.||   |
Human  2187 PGISLLSY----EASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRF---Q 2244

  Fly    86 LADP--WNSELDARQERPIPLQMDRRSGKVVG-SEDCLYLNVYTKHFNESEPPLPVMVYIYGGAF 147
            ..:|  |....||.:.|....|...|:....| |||||||||:..  ....|...|:|:.:....
Human  2245 APEPLNWTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYLNVFIP--QNVAPNASVLVFFHNTMD 2307

  Fly   148 R--------TGGAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLAL 204
            |        ..|:..:..|       :::.|..:||:...||||..||  :|.||.||.||:.||
Human  2308 REESEGWPAIDGSFLAAVG-------NLIVVTASYRVGVFGFLSSGSG--EVSGNWGLLDQVAAL 2363

  Fly   205 QWVSQHIRNFNGDPQNITLFGESAGA--ASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSD 267
            .||..|||.|.|||:.::|..:..||  ||:|.:........||.:|::|.||.|||
Human  2364 TWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSP-------- 2420

  Fly   268 GIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFIS-PRDRCFGFLN-----------PF- 319
                  |....:|...::.  :...:.|:.......:.:| .|.:....||           ||
Human  2421 ------AAVISHERAQQQA--IALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFH 2477

  Fly   320 --APVVGG--LVAAPFQQLMKEAWSCEVPLLLGGTSFEGLV---------------------YYP 359
              .||:.|  |...|.:.|.:..| .||.||:|.:..:||:                     :|.
Human  2478 YWGPVIDGHFLREPPARALKRSLW-VEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQ 2541

  Fly   360 FCQLDNGYMLELLKHEPAMVLPHEL------YQSMSVEERNTAADVLVKYHYGPRGITKSNITQI 418
            ..|...|......:.|.|....:.|      |.|.|....|...|..:             |..|
Human  2542 ALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFI-------------ICPI 2593

  Fly   419 LDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRF--DFDSPKLNLMRNQLCGDDIKRGVCHADDLG 481
            :|:.|   .|          ...|:...::|..  ::....|.|:.      |::..      ||
Human  2594 IDMAS---AW----------AKRARGNVFMYHAPENYGHGSLELLA------DVQFA------LG 2633

  Fly   482 YIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCP-------ETGPDPW---MPVSTKSP 536
            ..|:...:.:..|:. :.|:: :::...:.|.|:|:||.|       .|...||   :|.:....
Human  2634 LPFYPAYEGQFSLEE-KSLSL-KIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGEN 2696

  Fly   537 FKALNIGQQVECVTQVEKDGLK-----VWNRLYSDLK 568
            :|..:     |.:.  .:.|||     .|::..|.||
Human  2697 YKEFS-----ELLP--NRQGLKKADCSFWSKYISSLK 2726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	140/569 (25%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:459665
		Thyroglobulin_1	662..724	CDD:459665
		TY	730..>776	CDD:469630
		TY	<892..922	CDD:469630
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:429604
		Type II. /evidence=ECO:0000269|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	2130..2187		153/622 (25%)
		Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710	2188..2768		152/621 (24%)
		COesterase	2197..2718	CDD:395084	145/598 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2727..2768		153/622 (25%)