DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est6 and TG

DIOPT Version :9

Sequence 1:NP_524262.1 Gene:alpha-Est6 / 40902 FlyBaseID:FBgn0015574 Length:568 Species:Drosophila melanogaster
Sequence 2:NP_003226.4 Gene:TG / 7038 HGNCID:11764 Length:2768 Species:Homo sapiens


Alignment Length:622 Identity:153/622 - (24%)
Similarity:237/622 - (38%) Gaps:160/622 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 PGFKRFSCQSAGDADSKVVKLSV-GSVKGRRLS---GIYGDEFYSFEGIPFAKPPLGKARFVASQ 85
            ||....|.    :|....|.:|. |.:.||..:   |....:...|.|:|:|.|||.:.||   |
Human  2187 PGISLLSY----EASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRF---Q 2244

  Fly    86 LADP--WNSELDARQERPIPLQMDRRSGKVVG-SEDCLYLNVYTKHFNESEPPLPVMVYIYGGAF 147
            ..:|  |....||.:.|....|...|:....| |||||||||:..  ....|...|:|:.:....
Human  2245 APEPLNWTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYLNVFIP--QNVAPNASVLVFFHNTMD 2307

  Fly   148 R--------TGGAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLAL 204
            |        ..|:..:..|       :::.|..:||:...||||..||  :|.||.||.||:.||
Human  2308 REESEGWPAIDGSFLAAVG-------NLIVVTASYRVGVFGFLSSGSG--EVSGNWGLLDQVAAL 2363

  Fly   205 QWVSQHIRNFNGDPQNITLFGESAGA--ASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSD 267
            .||..|||.|.|||:.::|..:..||  ||:|.:........||.:|::|.||.|||        
Human  2364 TWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSP-------- 2420

  Fly   268 GIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFIS-PRDRCFGFLN-----------PF- 319
                  |....:|...::.  :...:.|:.......:.:| .|.:....||           || 
Human  2421 ------AAVISHERAQQQA--IALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFH 2477

  Fly   320 --APVVGG--LVAAPFQQLMKEAWSCEVPLLLGGTSFEGLV---------------------YYP 359
              .||:.|  |...|.:.|.:..| .||.||:|.:..:||:                     :|.
Human  2478 YWGPVIDGHFLREPPARALKRSLW-VEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQ 2541

  Fly   360 FCQLDNGYMLELLKHEPAMVLPHEL------YQSMSVEERNTAADVLVKYHYGPRGITKSNITQI 418
            ..|...|......:.|.|....:.|      |.|.|....|...|..:             |..|
Human  2542 ALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFI-------------ICPI 2593

  Fly   419 LDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRF--DFDSPKLNLMRNQLCGDDIKRGVCHADDLG 481
            :|:.|   .|          ...|:...::|..  ::....|.|:.      |::..      ||
Human  2594 IDMAS---AW----------AKRARGNVFMYHAPENYGHGSLELLA------DVQFA------LG 2633

  Fly   482 YIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCP-------ETGPDPW---MPVSTKSP 536
            ..|:...:.:..|:. :.|:: :::...:.|.|:|:||.|       .|...||   :|.:....
Human  2634 LPFYPAYEGQFSLEE-KSLSL-KIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGEN 2696

  Fly   537 FKALNIGQQVECVTQVEKDGLK-----VWNRLYSDLK 568
            :|..:     |.:.  .:.|||     .|::..|.||
Human  2697 YKEFS-----ELLP--NRQGLKKADCSFWSKYISSLK 2726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est6NP_524262.1 COesterase 35..534 CDD:278561 141/571 (25%)
Aes <133..325 CDD:223730 59/216 (27%)
TGNP_003226.4 TY 33..92 CDD:238114
TY 95..160 CDD:238114
TY 300..358 CDD:238114
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..545
Thyroglobulin_1 599..658 CDD:395039
Thyroglobulin_1 662..724 CDD:395039
TY 729..>776 CDD:412186
TY <892..922 CDD:412186
TY 1004..1073 CDD:238114
TY 1077..1145 CDD:238114
TY 1149..1210 CDD:238114
Type II. /evidence=ECO:0000269|PubMed:8797845 1456..1469
Ephrin_rec_like 1465..1510 CDD:400166
Type II. /evidence=ECO:0000269|PubMed:8797845 1470..1486
Type II. /evidence=ECO:0000269|PubMed:8797845 1487..1503
TY 1520..1567 CDD:214561
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1603..1723
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1724..1892
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1893..1995
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1996..2129
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 2130..2187 153/622 (25%)
Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710 2188..2768 152/621 (24%)
COesterase 2197..2718 CDD:395084 145/598 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2727..2768 153/622 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142806
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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