DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and LOC688542

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_038954018.1	Gene:	LOC688542 / 688542	RGDID:	1587637	Length:	559	Species:	Rattus norvegicus

Alignment Length:	592	Identity:	158/592 - (26%)
Similarity:	247/592 - (41%)	Gaps:	111/592 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 FKRFSCQSA--------------GDADSKVVKLSVGSVKGRRLSGIYGD-EFYSFEGIPFAKPPL 76
            :||..|.:|              .|:.|.:.....|.|:|..:.....| :.::|.||||||||:
  Rat     4 YKRPGCLNAVTCGLLLLVLHVRGQDSASPIRNTHTGQVRGSLVHVKDTDIDVHTFLGIPFAKPPV 68

  Fly    77 GKARFVASQLADPWNSELDARQERPIPLQMDRRSGK------------VVGSEDCLYLNVYTKHF 129
            |..||...:..:||:...||.....:.||.|...|.            :..||||||||:|....
  Rat    69 GPLRFAPPEAPEPWSGVRDATSHPAMCLQNDNMMGSEDMKIMKLILPPISMSEDCLYLNIYAPTH 133

  Fly   130 NESEPPLPVMVYIYGGAFRTGGAVKSKY-GPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPG 193
            ......|||||:|:|||...|.|  |.| |.....:.|||.|...|||..|||.|  :|.....|
  Rat   134 AHEGSNLPVMVWIHGGALTVGMA--SMYDGSMLAATEDVVVVTIQYRLGVLGFFS--TGDEHARG 194

  Fly   194 NAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLS 258
            |.|..||:.||:||.|:|.:|.|:|..:|:||||||..||...:..|.::||||.|||.||.::.
  Rat   195 NWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVVVL 259

  Fly   259 PWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFAPVV 323
            |.:.:..|:.::..:|..:|......|. :::.||..:..:::.             :|....::
  Rat   260 PDLISRSSEMVYRIVANLSGCAAVDSET-LMQCLRGKSEAEILD-------------INKVFKII 310

  Fly   324 GGLVAAPF-----QQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPHE 383
            ..:|...|     |:|:..|....||.::|              ::|        .|...:||..
  Rat   311 PAVVDGEFLPKHPQELLASANFHRVPSIIG--------------INN--------DEYGWILPMI 353

  Fly   384 LYQSMSVEE----------RNTA---------ADVLVKYHYGPRGITKSNITQILDLFSYKLFWH 429
            ...:..:||          ::||         .|:|::.:.|.....|:...|..::....:|
  Rat   354 FDSAQKIEEITRKTLPTVLKSTALKMMLPPECGDLLMEEYMGDTEDPKTLQAQFREMMGDFMF-- 416

  Fly   430 GIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKR---GVCHADDLGYIF-HKQAQA 490
            .|..:.::....:.||.|.|.|...|....         |:|.   ...|.|::..:| :.....
  Rat   417 VIPALQVAHFQRSHAPVYFYEFQHRSSFFK---------DVKPPHVKADHGDEVFLVFGYLVGDI 472

  Fly   491 KQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQVECVTQVEKD 555
            |.|....|.|..::::.....|||.|:||  ..|...|..:.....:..|:|...|....:..:
  Rat   473 KFPHTEEEELLSRKIMKYWANFARHGNPN--SEGLPHWPVMDHDDQYLQLDIQPSVGRALKARR- 534

  Fly   556 GLKVWNR 562
             ||.|.:
  Rat   535 -LKFWTK 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	149/554 (27%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	67/192 (35%)
LOC688542	XP_038954018.1	COesterase	30..538	CDD:395084	152/562 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910