DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and Ces2j

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	153/534 - (28%)
Similarity:	235/534 - (44%)	Gaps:	79/534 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FSCQSAGDADSKVVKLSVGSVKGRRL------SGIYGDEFYSFEGIPFAKPPLGKARFVASQLAD 88
            |..:...|:.|.:.....|.|:|..:      |||     ::|.||||||||:|..||...:..:
  Rat    41 FLTEQGQDSASPIRNTHTGQVRGSFVHVKDTKSGI-----HTFLGIPFAKPPVGPLRFAPPEDPE 100

  Fly    89 PWNSELDARQERPIPLQ--MDRRSG-------KVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYG 144
            ||:...||..:..:.||  |....|       |:..||||||||:|.......:..|||||:|:|
  Rat   101 PWSGVRDATSQPAMCLQTAMMNLEGMKETELTKLPMSEDCLYLNIYVPAHAHEDSNLPVMVWIHG 165

  Fly   145 GAFRTGGAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQ 209
            |.. .||:...........:.::|.|...|||..|||.|  :|.....||.|..||:.||:||.|
  Rat   166 GGL-VGGSASMNDASTLAATEEIVIVSIQYRLGVLGFFS--TGDQHARGNWGYLDQMAALRWVQQ 227

  Fly   210 HIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLA 274
            :|..|.|:..::|:||.|||..||...:..|.:|||||:|||.||..|.|.:.:..|:.::..:|
  Rat   228 NIAYFGGNRDSVTIFGVSAGGTSVSSHVVSPMSKGLFHRAIMQSGVALLPGLISDTSEVVYKTVA 292

  Fly   275 TSAGYEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFAPVVGGLVAAPF-----QQL 334
            ..:|.|....|. ::..||..:.::::.             :|....::.|:|...|     |:|
  Rat   293 NLSGCEASDSEA-LIRCLRAKSKQEILA-------------INQVFKMIPGVVDGKFLPKHPQEL 343

  Fly   335 MKEAWSCEVPLLLGGTSFE---------GLVYYPFCQLDNGYMLELLKHEPA-MVLPHELYQSMS 389
            :.......||.::|..:.|         || |:....:....:...||...| |:||.|
  Rat   344 LASKDFHPVPSIIGVNTDECGWGVPTILGL-YHIINNITRETLPAALKIAAAQMMLPPE------ 401

  Fly   390 VEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFD 454
                  ..|::::.:.|.....::...|..::....:|  .|..:.::....:|||.|.|.|...
  Rat   402 ------CIDLIMEEYMGDTEDAETLQAQFKEMLGDFIF--VIPALQVAHFQRSQAPVYFYEFQHL 458

  Fly   455 SPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQ-PLDSPEFLTIQRMVGILTTFARTGDP 518
            ...:..:|......|      |.||..::|........ .|...|.|..:|::.....|||||:|
  Rat   459 LSFIKQVRPFYPKAD------HGDDTVFVFGSYFWGMTFDLTEEEELLKRRVMKYWANFARTGNP 517

  Fly   519 NCPETGPD-PWMPV 531
            |    |.| |..||
  Rat   518 N----GEDLPHWPV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	152/529 (29%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	62/191 (32%)
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	151/525 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336343
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740