DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and LOC679149

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	155/546 - (28%)
Similarity:	230/546 - (42%)	Gaps:	120/546 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SKVVKLSVGSVKGR------RLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQ 98
            |.:....:|.|:|:      ..:|:     ::|.||||||||:|..||...:..:||:...|...
  Rat    33 SPIRNTHIGQVRGKLDHVKDTKAGV-----HTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTS 92

  Fly    99 ERPIPLQ------------MDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGG 151
            :..:.||            |..:...|..||||||||:|..........|||||:|:||...||.
  Rat    93 QPAMCLQNLDVINAEGLKEMKLKLPPVSMSEDCLYLNIYAPAHAHEGSNLPVMVWIHGGGLMTGM 157

  Fly   152 AVKSKYGPDYL-MSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFN 215
            |  |.|....| ::.|:|.|...|||..|||.|  :|.....||.|..||:.||:||.|:|.:|.
  Rat   158 A--SMYDGSLLTVNEDLVVVTIQYRLGVLGFFS--TGDEHARGNWGYLDQVAALRWVQQNIAHFG 218

  Fly   216 GDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYE 280
            |:|..:|:||||||...|...:..|.::||||.|||.||..|.|::.|..|:.....:|..:|.|
  Rat   219 GNPDRVTIFGESAGGTCVSTHVVSPMSQGLFHGAIMESGVALLPYLIADTSEMFSTMVAKVSGCE 283

  Fly   281 GPAEE-----------------------VPIL---EFLRNVNAEKLIGHDFISPRDRCFGFLNPF 319
            ....|                       ||.:   |||.....|.|...||           .|.
  Rat   284 AMDSEALVHCLRAKSEAEILAINKVVQMVPAVVDGEFLPRHPKELLASEDF-----------RPV 337

  Fly   320 APVVGGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPA-MVLPHE 383
            ..::|         :..:.:...:||::|.|..       ..:|....:..:||...| ::||.|
  Rat   338 PSIIG---------VNNDEYGWTIPLVMGTTQM-------IKELSRENLQAILKKTTAQLMLPLE 386

  Fly   384 LYQSMSVEERNTAADVLVKYHYG----PRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQA 444
                        .:|:|::.:.|    |:.: ::..|::::.|.:.     |..:.::....:.|
  Rat   387 ------------CSDLLMEEYMGDIEDPKTL-QAQFTELMEDFMFV-----IPALQVAHFQCSHA 433

  Fly   445 PTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDL----GYIFHKQAQAKQPLDSPEFLTIQRM 505
            |.|.|.|......|..:|......|      |.|::    ||.|.   ..|......|.|..:||
  Rat   434 PVYFYEFQHQITFLKDIRPPHVKAD------HGDEIPFVFGYFFW---DMKTDFTEEEKLLSRRM 489

  Fly   506 VGILTTFARTGDPNCPETGPDPWMPV 531
            :.....|||.|:||  ..|...| ||
  Rat   490 MKYWANFARHGNPN--SEGLSYW-PV 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	155/546 (28%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	75/218 (34%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	155/546 (28%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	46/106 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740