DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Bche

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	589	Identity:	166/589 - (28%)
Similarity:	253/589 - (42%)	Gaps:	125/589 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRFLILRCCPGFKRFSCQSAGDADSKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKAR 80
            |...||..|..|.:...:     :..::....|.|:|..:. |.|....:|.|||:|:||||..|
  Rat     7 FLLWILLLCMLFGKSHTE-----EDVIITTKTGRVRGLSMP-ILGGTVTAFLGIPYAQPPLGSLR 65

  Fly    81 FVASQLADPWNSELDARQERPIPLQ-MDRRSGKVVG----------SEDCLYLNVYTKHFNESEP 134
            |...|..:.|....:|.:......| :|:......|          |||||||||:.
  Rat    66 FKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWI-------- 122

  Fly   135 PLP------VMVYIYGGAFRTGGAVKSKYGPDYLMSRD-VVYVLFNYRLCSLGFLSMPSGKLDVP 192
            |:|      |||::|||.|:||.:....|...:|...: |:.|..|||:.:||||:.| |..:.|
  Rat   123 PVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFP-GNSEAP 186

  Fly   193 GNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSML 257
            ||.||.||.|||||:.::|..|.|:|:::||||||||||||...:..||:..||.:||:.|||..
  Rat   187 GNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSN 251

  Fly   258 SPW-VNAPDSDGIFCRLATSAGYEGPAE--EVPILEFLRNVNAEK-LIGHDFISPRDRCFGFLNP 318
            :|| |..|:.  ...|..|.|.:.|.::  |..|:..||:.:.:: |:....:.|.| ....:|
  Rat   252 APWAVKHPEE--ARNRTLTLAKFIGCSKENEKEIITCLRSKDPQEILLNEKLVLPSD-SIRSIN- 312

  Fly   319 FAPVVGG--LVAAPFQQL----MKEAWSCEVPLLLG-----GTSFEGLVY-YPFCQLDNGYMLEL 371
            |.|.|.|  |...|...|    :|.|     .:|:|     ||:|  ||| .|....||
  Rat   313 FGPTVDGDFLTDMPHTLLQLGKVKTA-----QILVGVNKDEGTAF--LVYGAPGFSKDN------ 364

  Fly   372 LKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHG-----I 431
                .:::...|..:.:::            |..|...:.|..|     || |.:.|.|     :
  Rat   365 ----DSLITRREFQEGLNM------------YFPGVSSLGKEAI-----LF-YYVDWLGDQTPEV 407

  Fly   432 HRVVL-----------------SRLSHAQAPTYLYRFDFDSPKL---NLMRNQLCGDDIKRGVCH 476
            :|...                 .:.:..:...:.|.|:..|.||   ..|           ||.|
  Rat   408 YREAFDDIIGDYNIICPALEFTKKFAELEINAFFYYFEHRSSKLPWPEWM-----------GVMH 461

  Fly   477 ADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPDPWMPVSTKSPFKALN 541
            ..::.::|....:.:......|.:..:.::.....||:.|.||..:.....| ||.|.:..|.|.
  Rat   462 GYEIEFVFGLPLERRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVW-PVFTSTEQKYLT 525

  Fly   542 IGQQ 545
            :..:
  Rat   526 LNTE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	158/557 (28%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	80/202 (40%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	161/575 (28%)
		Aes	<120..>272	CDD:223730	69/162 (43%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910