DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and NLGN2

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	609	Identity:	173/609 - (28%)
Similarity:	248/609 - (40%)	Gaps:	121/609 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PGFKRFSCQSAGDADSKVVKLSVGSVKG--RRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLA 87
            ||.......|.|:....||..:.|.|:|  |.|:.........|.|:|:|.||||..||...:..
Human    26 PGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAP 90

  Fly    88 DPWNSELDARQERP---------IPLQM------DRRSGKVV----GSEDCLYLNVY-------- 125
            ..|....:|....|         :|..|      |.......    .||||||||:|
Human    91 ASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPL 155

  Fly   126 TKHFNES--EPP---------LPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFN 173
            ||..:|:  .||         .|||::::||::..|      |:|.:.||       :|:....|
Human   156 TKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVATLN 213

  Fly   174 YRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMC 238
            |||..|||||  :|.....||.||.||:.||:|:|::|.:|.|||:.||:||..|||:.|:.::.
Human   214 YRLGVLGFLS--TGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLIL 276

  Fly   239 LPQAKGLFHKAIMMSGSMLSPW-VNAPDSDGIFCR-LATSAG--YEGPAEEVPILEFLRNVNAEK 299
            ...::|||.|||..||:.:|.| ||.....  :.| ||...|  .|..||.|   |.||...:.:
Human   277 SHHSEGLFQKAIAQSGTAISSWSVNYQPLK--YTRLLAAKVGCDREDSAEAV---ECLRRKPSRE 336

  Fly   300 LIGHDFISPRDRCFGFLNPFAPVV-GGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYY-PFCQ 362
            |:..|....|     :...|.||| |.:|....:.||::.......:|:|....|||.:. ...:
Human   337 LVDQDVQPAR-----YHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAE 396

  Fly   363 LDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVL---VKYHY---GPRGITKSNITQILDL 421
            .::|..........:..:.: ||....      ..|||   :|:.|   ..|...:.....:|.|
Human   397 SEDGVSASAFDFTVSNFVDN-LYGYPE------GKDVLRETIKFMYTDWADRDNGEMRRKTLLAL 454

  Fly   422 FSYKLFWHGIHRVVLSRLSHA--QAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIF 484
            |:... |  :...|.:...||  |:|.|.|.|        ....|..|........|.|:|.|:|
Human   455 FTDHQ-W--VAPAVATAKLHADYQSPVYFYTF--------YHHCQAEGRPEWADAAHGDELPYVF 508

  Fly   485 HKQAQAKQPLDSPEFLTIQRMVGIL-----TTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQ 544
            .........|....|.....|:..:     |.||:|||||.|       :|..||......|..:
Human   509 GVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP-------VPQDTKFIHTKPNRFE 566

  Fly   545 QVECVTQVEKDGLKVWNRLYSDLK 568
            :|            ||::..|..|
Human   567 EV------------VWSKFNSKEK 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	162/563 (29%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	76/211 (36%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	169/594 (28%)
		Aes	<170..>268	CDD:223730	41/106 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740