DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and si:dkey-30c15.17

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_003200472.2	Gene:	si:dkey-30c15.17 / 561375	ZFINID:	ZDB-GENE-060503-450	Length:	657	Species:	Danio rerio

Alignment Length:	568	Identity:	164/568 - (28%)
Similarity:	230/568 - (40%)	Gaps:	115/568 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QSAGDADSKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDAR 97
            :....||..||.| :|.|:|..|     ::.:.|.|||:|.||:|..|:.......||....:|.
Zfish   129 EDGSGADPVVVTL-LGRVRGLTL-----EKAHVFYGIPYADPPVGDKRWAPPSPVSPWLYTYNAT 187

  Fly    98 QERPIPLQM-----DRRSGKVVGSEDCLYLNVYTK-HFNESEP---PLPVMVYIYGGAFRTGGAV 153
            ..||..:||     .|.....| |||||||||:.. ..|.|.|   .|||||:|:||.|..|.|.
Zfish   188 FPRPACMQMCAGEFSRLCPPEV-SEDCLYLNVFVPVSVNLSLPKVTALPVMVWIHGGDFIAGSAS 251

  Fly   154 KSKYGPDYLMS-RDVVYVLFNYRLCSLGFLSMPSGK---LDVPGNAGLHDQLLALQWVSQHIRNF 214
            |..|...|:.: .:.|.|...|||.:.|||  .:||   ....||.|:.||..||.||.::|..|
Zfish   252 KPLYDGRYISNYSNTVVVNMEYRLGAFGFL--VTGKDPESSAVGNYGILDQQAALHWVQENIAAF 314

  Fly   215 NGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGI---FCRLATS 276
            .|||..:|||||||||.||...:.:..::.||..|.:.|.....|.....|:..:   |.:|...
Zfish   315 GGDPNKVTLFGESAGAQSVSLHLMMQSSETLFRHAAIQSLPFSLPLKTRWDAMKLGWDFAKLTNC 379

  Fly   277 AGYEGP------AEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPF---APVVGG--LVAAP 330
            :.::.|      :|:|        :||:...|...|:|    |.||..|   .|.:.|  |...|
Zfish   380 SVFDLPCMRSLSSEDV--------LNAQIKSGSKIINP----FRFLEVFETWGPFIDGQLLKEQP 432

  Fly   331 FQQLMKEAWSCEVPLLLGGTSFEGL--VYYPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEER 393
            .....|..|....|::||.||.||:  ||..|.:  :..|||.:.:..|:...|
Zfish   433 ITAFQKGHWQSYKPVILGTTSEEGVMFVYRNFNK--SVSMLECVLYTAAIFKQH----------- 484

  Fly   394 NTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSRL-----------SHAQA--- 444
              |..:|.||                    ...:.:...||:||::           ..|::
Zfish   485 --ALKILHKY--------------------IPFYRNQDRRVMLSQMVTDYVFSCPARQSARSGVK 527

  Fly   445 ---PTYLYRFDFDSPKLNLMRN-QLCGDDIKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRM 505
               ..::|.||......|:... ..|.:.    .||..:|.::|.............|.|...||
Zfish   528 VGGAVWMYVFDHAPSDPNIWAELTFCYNH----SCHGAELPFLFDSAPSTNFTFTPQERLLANRM 588

  Fly   506 VGILTTFARTGDPN--------CPETGPDPWMPVSTKSPFKALNIGQQ 545
            ......||.|||||        |.|.....|...:....:..||:..|
Zfish   589 ACYWGMFAHTGDPNSRDEQTHFCREQRLPVWPRYTDIGGWTILNLTLQ 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	161/553 (29%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	71/210 (34%)
si:dkey-30c15.17	XP_003200472.2	COesterase	134..651	CDD:306613	164/563 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840