Protein Alignment alpha-Est6 and NLGN3

DIOPT Version :9

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 655
• Identity: 163/655 - (24%)
• Similarity: 252/655 - (38%)
• Gaps: 197/655 - (30%)

  Fly     1 MWKLCQPRSRS--------RIKCFRFLILRCCPGFKRFSCQSAGDADSKVVKLSVGSVKGRRL-- 55
            ||....|.|.|        |..|...       .|...:.:::..|.:..|....|.::|.|:
Human     1 MWLRLGPPSLSLSPKPTVGRSLCLTL-------WFLSLALRASTQAPAPTVNTHFGKLRGARVPL 58

  Fly    56 -SGIYG--DEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPI-PLQMDRRSGKVV-- 114
             |.|.|  |::.   |:|:|.||:|:.||:..:....|:...:|....|: |..:.....:|:
Human    59 PSEILGPVDQYL---GVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLP 120

  Fly   115 ----------------GSEDCLYLNVYT------------------------------------- 126
                            .:|||||||||.
Human   121 VWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLAD 185

  Fly   127 KHFNESEP-----PLPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFNYRLCSLG 180
            ...:|.|.     ..||||||:||::..|      |::.:.||       :|:.:..|||:..||
Human   186 NDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYG-------NVIVITLNYRVGVLG 243

  Fly   181 FLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGL 245
            |||  :|.....||.||.||:.||:|||::|..|.|||:.||:||...||:.|..:.....::||
Human   244 FLS--TGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGL 306

  Fly   246 FHKAIMMSGSMLSPW-VNAPD-------SDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIG 302
            |.:||:.|||.||.| ||...       :|.:.|.:         .:.|.:::.||..:|::|:.
Human   307 FQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNV---------LDTVDMVDCLRQKSAKELVE 362

  Fly   303 HDFISPRDRCFGFLNPFAPVV-GGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNG 366
            .|....|     :...|.||: |.::....:.||::.......::||....||
Human   363 QDIQPAR-----YHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEG------------ 410

  Fly   367 YMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYG-PRGITKSNITQILDLFSY------ 424
                 ||....:|.|.:   .:|..:.:.:....|...|| |.|  |..:.:.:. |.|
Human   411 -----LKFVEGVVDPED---GVSGTDFDYSVSNFVDNLYGYPEG--KDTLRETIK-FMYTDWADR 464

  Fly   425 -----------KLF----WHGIHRVVLSRLSHAQ--APTYLYRFDFDSPKLNLMRNQLCGDDIK- 471
                       .||    |  :...|::...||:  :|||.|.|           ...|...:|
Human   465 DNPETRRKTLVALFTDHQW--VEPSVVTADLHARYGSPTYFYAF-----------YHHCQSLMKP 516

  Fly   472 --RGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGIL-----TTFARTGDPNCPETGPDPWM 529
              ....|.|::.|:|.........|....|.....|:..:     |.||:|||||.|       :
Human   517 AWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKP-------V 574

  Fly   530 PVSTK 534
            |..||
Human   575 PQDTK 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	153/611 (25%)
		Aes	<133..325	CDD:223730	71/211 (34%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	155/613 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		2/24 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740