DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Nlg4

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster

Alignment Length:	723	Identity:	176/723 - (24%)
Similarity:	257/723 - (35%)	Gaps:	246/723 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 CQSAGDAD--------SKVVKLSVGSVKGRRLSGIY--GDEF------YSFEGIPFAKPPLGKAR 80
            |..|..||        .::|:...|     ||.|:.  .|.|      ..|.|:|:|.||..:.|
  Fly    25 CAGASTADIYKGARLGHRIVQTRYG-----RLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNR 84

  Fly    81 FVASQLADPWN--------------------SELDARQERP----------IPLQMDRRSGKVVG 115
            |..::...||:                    :|..|.::.|          :|...::
  Fly    85 FSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQ------- 142

  Fly   116 SEDCLYLNVYTK-HFNESEPPLPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFN 173
            |||||||||::. :...:|..|||:|:|:|.:|...      |:|.:.||       :||.|..|
  Fly   143 SEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYG-------EVVVVTLN 200

  Fly   174 YRLCSLGFLSM---PSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHF 235
            |||..||||:.   |.....| .|.||.||:.||.|:.|:|:.|.|||.::||.|...|||.:::
  Fly   201 YRLGILGFLNANPNPHAHARV-ANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINY 264

  Fly   236 MMCLP-QAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAE----EVPILEFLRNV 295
            :|..| ..:||||:||:||||..|.|....|......:||.......|.:    ...|::.||:|
  Fly   265 LMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDV 329

  Fly   296 NAEKLIGHDFISPRDRCFGFLNPFAPVVGGLVAAPFQQLMKEAWSCEVPLLL------------- 347
            ..|.|...|..:|     .||..|.|.|.|:|..|...      :.::..|:
  Fly   330 PLEDLYLADIQAP-----NFLTSFGPSVDGVVIRPGHS------NLDIDDLMARNSRRSSADSGF 383

  Fly   348 ---------------------GGTSFEGLVYYPFCQLDNGYM-------LELLKHEPAM------ 378
                                 .|:||.|           ||.       :.:..|...:
  Fly   384 QSSAGGGGGQGGGAGGGGGGGSGSSFGG-----------GYFGGSGAGTMNMGGHYDVLFGVVTG 437

  Fly   379 -----VLPHELYQSMSVEERNTAADVLVK--YHYGPRGITKSNITQILDLFSYKLFW-----HGI 431
                 ...|::......|.|:......|:  |:|....|..:.:.:..|       |     |.|
  Fly   438 ESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTD-------WDRTSQHPI 495

  Fly   432 HR--VVLSRLSHAQ--AP-------------------------------------------TYLY 449
            :.  ..::.||.||  ||                                           .|.|
  Fly   496 NTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFY 560

  Fly   450 RFDFDSPKLNLMRNQLCGDDIKR-GVCHADDLGYIFHKQ-----AQAKQPLDSPEFLTIQRMVGI 508
            .||:.:..         ||..:| |..|.:||.|||...     :...|.....|....:.::..
  Fly   561 VFDYQTKD---------GDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIF 616

  Fly   509 LTTFARTGDPNCPETGPDPWMPVSTK------------SPF--KALNIGQQVECVTQVEKDGLKV 559
            .|.|||||:|| .....|..:|||.:            .|.  |.|.||.:...........|.:
  Fly   617 WTNFARTGNPN-EHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSI 680

  Fly   560 WNRLYSDL 567
            |.||..:|
  Fly   681 WLRLIPEL 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	165/671 (25%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	76/205 (37%)
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	168/696 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810