DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and alpha-Est1

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	248/552 - (44%)
Similarity:	324/552 - (58%)	Gaps:	35/552 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GDADSKVVKLSVGSVKGRRLSGIYGDEFY-SFEGIPFAKPPLGKARFVASQLADPWNSELDARQE 99
            |...:|||....|.|:|.|...:|.:|.| :|||||||:||:|:.||.|.|...||....|....
  Fly    28 GTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYP 92

  Fly   100 RPIPLQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMS 164
            |..|:|.......|.|||||||||||:|.. .|:.||||:|:||||.|:.|.|.:..|.|||.|.
  Fly    93 RAKPMQKHFVLSIVEGSEDCLYLNVYSKRL-RSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQ 156

  Fly   165 RDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAG 229
            :|||.|.||||:.:|||||:....|||||||||.||::||:|:||:|..|||||||||:.|||||
  Fly   157 QDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAG 221

  Fly   230 AASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRN 294
            |||||.:|...|.:||||||||.||||...|.|.|.....: |||...||.|...|..:..:|:.
  Fly   222 AASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRWAY-RLACQLGYSGSENEKEVFRYLQK 285

  Fly   295 VNAEKLI--GHDFISPRDRCFGFLNPFAPVVGGLVAAP------FQQLMKEAWSCEVPLLLGGTS 351
            ..|.::.  |...:|..:|....|.||.|||...:...      .::::.|||..::||:|||.|
  Fly   286 APASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNS 350

  Fly   352 FEGLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAA---DVLVKYHY-----GPR 408
            ||||..|.....|..:||...:    :::|.|      :.|::|.:   |:|.::..     ..|
  Fly   351 FEGLFSYQSTLHDEEHMLSAFE----VLIPRE------IREKSTQSHLKDLLRQFKVDNFDDATR 405

  Fly   409 GITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQA-PTYLYRFDFDSPKLNLMRNQLCGDDIKR 472
            |  :....:.|.:.|.|.|||||||.||:|||||.| ||||||||.|||..|..|..:||..: |
  Fly   406 G--RMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHV-R 467

  Fly   473 GVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPDPWMPVSTKSPF 537
            ||.|||||.|:|:.....|....|.|:.||||:||:...|||..:||||:.||..|..:..|.|.
  Fly   468 GVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQ 532

  Fly   538 KALNIGQQVECVTQVEKDGLKVWNRLY--SDL 567
            ..||||:|:|.:...|....::|:|||  :||
  Fly   533 MCLNIGKQLEFIVLPESKQNRIWDRLYDKNDL 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	233/515 (45%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	101/193 (52%)
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	239/527 (45%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	71/116 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467372
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	1	0.950	-	0	Normalized mean entropy	S4180
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.850