DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	223/551 - (40%)
Similarity:	322/551 - (58%)	Gaps:	46/551 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DSKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIP 103
            :|..|..:.|.|.|::.:|:||||:.|||.||:|:||:|..||:|....:||:..||..:....|
  Fly     2 ESLQVNTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKP 66

  Fly   104 LQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRDVV 168
            ||.:..|.::.|.|||||||||.|.. :|..|||::|:.:||.|..|...|..:.|||.|.||||
  Fly    67 LQFNHYSKQLEGVEDCLYLNVYAKEL-DSPRPLPLIVFFFGGGFEKGDPTKELHSPDYFMMRDVV 130

  Fly   169 YVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASV 233
            .|..:||:..|||||:....:.|||||||.|||||::|:.::...|||||:|:|.||||||||||
  Fly   131 VVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASV 195

  Fly   234 HFMMCLPQAKGLFHKAIMMSGSMLSPWV-----NAPDSDGIFCRLATSAGYEGPAEEVP---ILE 290
            |::|..|:|:|||||||:.||::|..|.     |.|.      |||.:.|.|. ||.|.   :|:
  Fly   196 HYLMLNPKAEGLFHKAILQSGNVLCSWALCTIKNLPH------RLAVNLGMES-AEHVTDAMVLD 253

  Fly   291 FLRNVNAEKLIGHDFISPRDRCFGFLNPFAPVVGGLVAAPF-----------QQLMKEAWSCEVP 344
            ||:.:..|||:....:|..:.....:..|.|:|     .|:           |:|:.:||...:|
  Fly   254 FLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMV-----EPYKTEHCALPNHPQELLDKAWGNRIP 313

  Fly   345 LLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYG--- 406
            :|:.|||||||:.|...|: ..|:|..||.||..:||.::.:::...........|.:.|:|
  Fly   314 VLMSGTSFEGLLMYARVQM-APYLLTSLKKEPEHMLPLDVKRNLPQALARHLGQRLQETHFGGND 377

  Fly   407 PRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIK 471
            |..::..::....:..|||:|||.|.:.:.||:..:.|.|||||||||||..|..|.:.|||.:
  Fly   378 PSAMSPESLKAYCEYASYKVFWHPILKTLRSRVKSSSASTYLYRFDFDSPTFNHQRLKYCGDKL- 441

  Fly   472 RGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNC-------PETGPDPWM 529
            |||.|.||..|:::.....|....:||||||:||:.:||:||||.:|||       |..  ..|.
  Fly   442 RGVAHVDDHSYLWYGDFSWKLDKHTPEFLTIERMIDMLTSFARTSNPNCKLIQDQLPRA--KEWK 504

  Fly   530 PVSTKSPFKALNIGQQVECVTQVEKDGLKVW 560
            |:::||..:.|||.:.::.:...|...|:||
  Fly   505 PLNSKSALECLNISENIKMMELPELQKLRVW 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	214/523 (41%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	90/199 (45%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	219/542 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467374
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.890