DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and alpha-Est10

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	231/545 - (42%)
Similarity:	315/545 - (57%)	Gaps:	32/545 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIPLQM 106
            |:|...|.|:|.:.:.|:|..::|||.|||||||:|..||.|.:..:||:.|||.......|||.
  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQT 114

  Fly   107 DRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRDVVYVL 171
            .....|..|||||||||||.|.. :.:...||||:||||.::.|.|.:..|.||:.||:|||.|.
  Fly   115 HMFFRKYAGSEDCLYLNVYVKDL-QPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMSKDVVIVT 178

  Fly   172 FNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFM 236
            ..|||.:|||||:...:|:|||||||.||::||:||.|:|..|.||..||||||||||.||.||:
  Fly   179 VAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFL 243

  Fly   237 MCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLI 301
            ...||.:||.||||:||||:|.||...|.::..: |||...||.|..::..|.||||:::..:::
  Fly   244 ALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAY-RLAQKLGYTGDNKDKAIFEFLRSMSGGEIV 307

  Fly   302 --GHDFISPRDRCFGFLNPFAPVV------GGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYY 358
              ....:|..::....|..|.|||      ..:||....:||:.:||..:|::.||||||||::|
  Fly   308 KATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFY 372

  Fly   359 PFCQLDNGYMLELLKHEPAM---------VLPHELYQSMSVEERNTAADVLVKYHYGPRGITKSN 414
            |           .:...||.         :||.:|..::..:.|......|.|.::|.....::|
  Fly   373 P-----------EVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPCNQAN 426

  Fly   415 ITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADD 479
            :.:.|:|.||:.|||.|:|..|:|:..:.|||||||||.||...|.:|..|||..: |||||.||
  Fly   427 MMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGHQM-RGVCHGDD 490

  Fly   480 LGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQ 544
            |.||||.....:...||||...|..||.:.|:||..|||||.......:.|:...:.||.||||.
  Fly   491 LCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPNCESIKSLKFAPIENVTNFKCLNIGD 555

  Fly   545 QVECVTQVEKDGLK-VWNRLYSDLK 568
            |.|.:...|...:: |||..|:..|
  Fly   556 QFEVMALPELQKIEPVWNSFYAPNK 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	217/508 (43%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	93/199 (47%)
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	216/505 (43%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	79/148 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467378
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D8477at33392
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900