DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Est-Q

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	155/571 - (27%)
Similarity:	255/571 - (44%)	Gaps:	111/571 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FLILRCCPGFKRFSCQSAGDADSKVVKLSV----GSVKGRRLSGIYGDE-FYSFEGIPFAKPPLG 77
            ||::....|      |.|..:::..|.:.:    |:|.|......:.|. |..|.|||||:||:.
  Fly    23 FLVIFLTGG------QGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIE 81

  Fly    78 KARFVASQLADPWNSELDA---RQERPIPLQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVM 139
            :.||.......||...|:|   .|..|:...:|.:... ...||||.|:||||:.:.|:   |||
  Fly    82 ELRFRPPVARSPWTGTLNALNFGQRCPVITNLDSQMSD-AELEDCLTLSVYTKNLSASQ---PVM 142

  Fly   140 VYIYGGAFRTGGAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLAL 204
            .|||||.|..|.:  ..:.|:||:.:|||.|:..||:.:||:||..:.:|  ||||.:.|.|:||
  Fly   143 FYIYGGGFYNGSS--EDHPPNYLLEKDVVLVVPQYRVGALGWLSTYTEEL--PGNAPIADILMAL 203

  Fly   205 QWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQ-AKGLFHKAIMMSGSMLSPWVNAPDSDG 268
            .||..||.:|.||||.:|:||:||||.....::..|: ...:|.:||:.|||:.:.|....|...
  Fly   204 DWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKA 268

  Fly   269 IFCRLATSAGYEG---------PAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFAPVVG 324
            ...|:....|..|         ..::..:::.|:...:|.                   |:|:||
  Fly   269 QSRRICIQLGCSGCEQHDQLVKCIQKAKVIDILKATASES-------------------FSPIVG 314

  Fly   325 ---GLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQ 386
               |::.....:|:| ::..::|:|.|           |.|.|..::  |..:..|:........
  Fly   315 DLHGILPQQPSELVK-SYRRQIPILTG-----------FTQHDGSFV--LASYYDALAAKVANVS 365

  Fly   387 SMSVEERNTAADVLVKYHYGPRGITKSNITQIL-------------------DLFSYKLFWHGIH 432
            |:||.:.:...:.||.   ...|:|.:.:.::|                   || :..:|.....
  Fly   366 SLSVRQFSQGINDLVN---DTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDL-TTNIFMKSPV 426

  Fly   433 RVVLSRLSHAQ--APTYLYRFDFDSPKLNLMRNQLCGDD---IKRGVCHADDLGYIFHKQAQAKQ 492
            ..:.:::...|  .|.|:|.|:::......  ....|:.   ...||.|::|..|:|     |..
  Fly   427 ITLATKMYTQQRSTPVYVYSFEYEGTYTRF--GYEFGNSHYPFNGGVHHSNDNIYLF-----ATH 484

  Fly   493 PLDSPEFLTIQRMVGILTTFARTGDPNCPETGPDPWMPVSTKS-PFKALNI 542
            ||:..:....|:||.:.|:||..|.|.       ...|:|:.| |:..||:
  Fly   485 PLEGQDTQMSQKMVDVWTSFAIEGVPR-------NLSPLSSASGPYNKLNL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	147/543 (27%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	66/204 (32%)
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	150/549 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	49/109 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.970