Protein Alignment alpha-Est6 and Ces3a

DIOPT Version :9

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 572
• Identity: 159/572 - (27%)
• Similarity: 236/572 - (41%)
• Gaps: 117/572 - (20%)

  Fly    43 VKLSVGSVKGRRLSGIYGDEFYS-FEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIPLQ- 105
            |...:|.|:||::.....|...: |.|||||:.|||..||.|.....||....||....|:.||
Mouse    39 VDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQD 103

  Fly   106 MDRRSG---------KVVG-SEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTG------GAVK 154
            ::|.|.         |:.. |||||.||:|:.....:....||||:|:||:...|      |:..
Mouse   104 VERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSHDGSAL 168

  Fly   155 SKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQ 219
            :.||       |||.|...|||...||||  :|...:|||.|..|.:.||:||..:|..|.|||.
Mouse   169 AAYG-------DVVVVTVQYRLGIFGFLS--TGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPN 224

  Fly   220 NITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLS-------PWVNAPD-SDGIFCRLATS 276
            .:|:||.|||...|..::..|.:.||||:||..||.::|       .|..|.: ::.:.|
Mouse   225 CVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLNAWSEAQNFANSVAC----- 284

  Fly   277 AGYEGPAEEVPIL------EFL--RNVNAEKLIGHDFISPRDRCFGFLNPFAPVVGGLVAAPFQQ 333
             |...|||.|..|      :.:  :|||....:...|...|.                     |:
Mouse   285 -GSASPAELVQCLLQKEGKDLITKKNVNISYTVNDSFFPQRP---------------------QK 327

  Fly   334 LMKEAWSCEVPLLLGGTSFE-GLVYYPFC-------QLDNGYMLE----LLKHEPAMVLPHELYQ 386
            |:.......||.|||.|:.| |.:...|.       .|....:||    ||.|   |.||.|:..
Mouse   328 LLANKQFPTVPYLLGVTNHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAH---MQLPPEIMP 389

  Fly   387 SMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSR-LSHAQAPTYLYR 450
            ::..|..:..:|         ...|:..:.::|...:..     |..::.|: |..|..|.:||.
Mouse   390 TVIDEYLDNGSD---------ESATRYALQELLGDITLV-----IPTLIFSKYLQDAGCPVFLYE 440

  Fly   451 FDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQ--AQAKQPLDSPEFLTIQRMVGIL---- 509
            |..........:......|      |:.:..::|...  ......|..||....::.:.:.
Mouse   441 FQHTPSSFAKFKPAWVKAD------HSSENAFVFGGPFLTDESSLLAFPEATEEEKQLSLTMMAQ 499

  Fly   510 -TTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQVECVTQVEKDGLKVW 560
             :.|||||:||  ..|..||..::....:  |.||.:.....:::|..|:.|
Mouse   500 WSQFARTGNPN--GKGLPPWPQLNQLEQY--LEIGLEPRTGVKLKKGRLQFW 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	153/544 (28%)
		Aes	<133..325	CDD:223730	68/213 (32%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	158/570 (28%)
		Aes	75..>245	CDD:223730	65/178 (37%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740