DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Jhedup

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	165/519 - (31%)
Similarity:	247/519 - (47%)	Gaps:	46/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GFKRFSCQSAGDADSKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPW 90
            |...|...:.||: ..|....:|.::|..:.|....||.:|.|||||:||:|..|.......:||
  Fly     7 GVLLFVAVAVGDS-LDVCLEDMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPW 70

  Fly    91 NSELDARQERPIPLQMD--RRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAV 153
            ...|||...:...:|..  .:...::|.||||||||| :..|.:|..|||||||:||.|.:|.|.
  Fly    71 EGVLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVY-RPKNRAEDKLPVMVYIHGGGFFSGSAH 134

  Fly   154 KSKYGPDYLM-SRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGD 217
            ....||:||| :..||.|..||||...||||  :|...:|||.|..||.|||||:.:||..|.||
  Fly   135 PMASGPEYLMDTNKVVMVTMNYRLGPFGFLS--TGDEHMPGNFGFKDQRLALQWIQKHIATFGGD 197

  Fly   218 PQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSM-LSPWVNAPDSDGIFCRLATSAGYEG 281
            |:.:|:.|.|||..|.|..|..|.:||||..::.::|:| ||......|......||......:
  Fly   198 PKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAID- 261

  Fly   282 PAEEV---PILEFLRNVNAEK-LIGHDFISPRDRCFGFLNPFAPVVGGLVA-APFQQLMKEAWSC 341
            .||.:   .:.|.||||..:| |:..|.:...|..     |....:..|.| :|...|:::....
  Fly   262 QAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNM-----PHLTTLPVLEAPSPDAFLVEDPLDA 321

  Fly   342 -------EVPLLLGGTSFEG----LVYYPFC--QLDNGYMLELLKHEPAMVLPHELYQSMSVEER 393
                   ::|.:|..:|..|    .:...|.  :|...:....|:|   |.|...|.:...|:
  Fly   322 HRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEH---MALLLNLPEGTPVQ-- 381

  Fly   394 NTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHA---QAPTYLYRFDFDS 455
             ..:::|..|.:....:....:.::.::.....|::.|:..:.|.:::|   :.|.::|.|:|..
  Fly   382 -MVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAG 445

  Fly   456 PKLNLMRNQLCG--DDIKRGVCHADD-LGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTG 516
              ||.:.....|  ||...|..|.|| |..|....:....|.||.:...||||..::|.||:||
  Fly   446 --LNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	163/510 (32%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	79/197 (40%)
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	159/494 (32%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	54/106 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440398
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800