DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Gli

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	141/553 - (25%)
Similarity:	226/553 - (40%)	Gaps:	108/553 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 FEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIPLQMDRRSGKVVG----SEDCLYLNVYT 126
            |.|||:|.||..:.||...::...|.. |.|....|...|..|.:|...|    .|||||||||:
  Fly   178 FLGIPYALPPTFEGRFKPPRVHRGWQL-LQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYS 241

  Fly   127 KHFNES-EPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSR--DVVYVLFNYRLCSLGFLSMPSGK 188
            ...... ....||||||:||.|..|.   |.....::::.  |||.|..||||.:|||||  :|.
  Fly   242 PKTGAGVAQKYPVMVYIHGGEFIRGA---SNLFQGHILASFYDVVVVTLNYRLGALGFLS--TGD 301

  Fly   189 LDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMS 253
            .:.|||.|:.||.:||:||..:|..||||..:|||||..||.||...:|..||.:.:..:.|..|
  Fly   302 ENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQS 366

  Fly   254 GSMLSPWV------NAPDSDGIF-----CRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFIS 307
            ||.|:.|.      .|.::..:.     |.:.:|         ..::..||...:...:|:...|
  Fly   367 GSALADWALIQDKYRAQNTSRVLGQLLGCSIESS---------WKLVNCLRTGRSFYELGNAEFS 422

  Fly   308 PRDRCFGFLNPFAPVVGGLVAAP----FQQLMKEAW----------------SCEVPLLLGGTSF 352
            |:...|    |:.||:......|    ::...::.|                :..:..:.|.|:.
  Fly   423 PQVGSF----PWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQ 483

  Fly   353 EGLVYY-------PFCQLDNGYMLELLKHE----PAMVLPHELYQSMSVEERNTAADVLVKYHY- 405
            |...:.       |:.:||..:..:.::..    ...:.|:.:|::             :||.|
  Fly   484 EAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEA-------------IKYIYT 535

  Fly   406 ---GPRG---ITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQ 464
               .|..   |....|..:.||: |:.....:.:::|.:    :.|.|:|..:.....|||.:.:
  Fly   536 FWPDPNNNTIIRDQYINMLSDLY-YRAPVDQMVKLMLEQ----KVPVYMYVLNTTVEALNLPQWR 595

  Fly   465 LCGDDIKR----GVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPET-- 523
            ....||:|    |....|...:...:..|.....|:...:: ...:...|.|||.|:|...:.
  Fly   596 KYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMS-HFFMQTYTNFARYGNPTPQQVLG 659

  Fly   524 --------GPDPWMPVSTKSPFKALNIGQQVEC 548
                    |...::.::|......|...:|.||
  Fly   660 MHFQRAYQGEIRYLNINTTYNSSILLNYRQTEC 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	136/537 (25%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	70/204 (34%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	141/553 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440433
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.740