DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and CG9287

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	151/566 - (26%)
Similarity:	229/566 - (40%)	Gaps:	128/566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DADSKVVKLSVGSVKGRRLSGIYGD-EFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQER 100
            :.|:.|...::||::|:.|...:.. |...|..:.:|:||.|..||.|.:..:||...:||..|:
  Fly    31 EKDTIVELPTLGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEK 95

  Fly   101 ---PIPLQMD--RRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPD 160
               |..:.||  ||...|:..||||.:.:.|.:....   |||:|||:|.....|.  .|:..||
  Fly    96 IGCPSVVSMDSLRRLDDVLDVEDCLTMTITTPNVTSR---LPVLVYIHGEYLYEGS--NSEAPPD 155

  Fly   161 YLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFG 225
            ||:.:|||.|...|||...||||..:.  ::|||||..|..||||:|...|:.|.|||..:|:.|
  Fly   156 YLLEKDVVLVTPQYRLGPFGFLSTKTD--EIPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAG 218

  Fly   226 ESAGAASVHFMMCLPQA-KGLFHKAIMMSGSMLSPWVNAPD-----------SDGIFCRLATSAG 278
            :..|||..|.:...|.. :||||:.|..|||.:.|.....|           :|   |::.|...
  Fly   219 QVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKAD---CKMVTVRD 280

  Fly   279 YEGPAEEVPILEFLRNVNAEKL------IGHDFISPRDRCFGFLNPFAPVVGGL---VAAPFQQL 334
            ......|:..||.|.......|      |||                   .||:   :..|...|
  Fly   281 LNTCLMELTALELLTAFMEHALEKSDLGIGH-------------------TGGIQFTIGGPSGVL 326

  Fly   335 MKEAWSCEVPLLLGGTSFEGLVYYPF---CQLDNG--YMLELLKHEPAMVLPHELYQSMSVEERN 394
            .|..:.     |:..|:|.    ||.   |..:.|  .:.|::.::....:|.:.|.:.:.
  Fly   327 PKHPYD-----LMLETNFS----YPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNY---- 378

  Fly   395 TAADVLVKYHYGPRGITKSNITQIL------DLFSYKLFWHGIHRVVLSRL-------------- 439
              .|.:::...|      ::.|.:|      |.|:..|..:|....::.||
  Fly   379 --IDHVIRQTVG------TDKTMLLTSFVTHDFFNRNLMENGTFDTLIPRLIDVAGTLNHKLPVL 435

  Fly   440 -------SHAQAPTYLYRFDFD---------SPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQA 488
                   .|....|:||.||:.         ..:.||.      ...|.||...|:..|:|....
  Fly   436 LALNMNNKHNPDNTFLYSFDYAGEFNRYKEMDEETNLQ------SPFKAGVSLTDEALYLFPYPE 494

  Fly   489 QAKQPLDSPEFLTIQRMVGILTTFARTGDP-NCPETGPDPWMPVST 533
            ...: |..|:.....|||.:.|.|..:|:| .....|  .|.|::|
  Fly   495 HVTR-LSRPDQSMAHRMVELWTNFVISGNPLGSARVG--YWPPMTT 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	151/566 (27%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	68/209 (33%)
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	151/566 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467462
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900