DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Glt

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	149/553 - (26%)
Similarity:	249/553 - (45%)	Gaps:	103/553 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VGSVKGRRLSG---IYGDEFYSFEGIPFAKPPLGKARFVASQLADP--WNSELDARQERP----I 102
            ||.:.|  :||   |......:|.||.:.....|.|||   |.|.|  :...::|..:.|    .
  Fly    67 VGQILG--ISGHKTIANRPVNAFLGIRYGTVGGGLARF---QAAQPIGYQGRVNATVQSPNCAQF 126

  Fly   103 P----LQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLM 163
            |    |::....|:.|  :|||.|::|..   |....|||:|:::|.....||:.:::  |||::
  Fly   127 PELDRLRLSESRGENV--DDCLTLDIYAP---EGANQLPVLVFVHGEMLFDGGSEEAQ--PDYVL 184

  Fly   164 SRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESA 228
            .:||:.|..||||...||||..:.:|  |||..|.|..|||:|:.:::.:|.|:...:||.|::.
  Fly   185 EKDVLLVSINYRLAPFGFLSALTDEL--PGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAG 247

  Fly   229 GAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWV--NAP-DSDGIFCRLA---------TSAGYEG 281
            ||...|.:....:|..||.:.|:.||:.|:|::  |.| |:...|.|||         ::.|.:
  Fly   248 GATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLK- 311

  Fly   282 PAEEVPILEFLRNVNAEKLI-GHDFISPRDRCFGF--LNPFAPVVG---GLVAAPFQQLMKEAWS 340
                 |:.:.|..:...:|: ..:.:..::...|.  |..|..|||   |.:.:....|...: |
  Fly   312 -----PLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNS-S 370

  Fly   341 CEVPLLLGGTS-----FEGLVYYPFCQLD----NGYMLELLKHEPAMVLPHELYQSMSVEE---- 392
            ..:|:::|.|.     ....:|....:|.    :.|:..:|:| .|....|.|::..::.|
  Fly   371 LALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRH-TAPPSEHRLWKQWALREIFTP 434

  Fly   393 --RNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSRL--SHAQAPTYLYRFDF 453
              ..||:             .::....:|:|.:|.|:    ...|::.:  |:...|.|||.||:
  Fly   435 IQEQTAS-------------LQTVAPGLLELSNYILY----RAPVINSISQSYRSVPAYLYTFDY 482

  Fly   454 --DSPKLNLMRNQL-CGDDIKRGVCHADDLGYIFHKQAQAKQ--PLDSPEFLTIQR-MVGILTTF 512
              :..:...:.|.| .|.|...    :||..|:|....:|.:  |||.    ::.| :|.:...|
  Fly   483 RGEHHRFGHLSNPLPFGVDASL----SDDSVYLFPYPPEASRLNPLDR----SLSRALVTMWVNF 539

  Fly   513 ARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQ 545
            |.||.|| |.:|..| ...|...||......||
  Fly   540 ATTGVPN-PSSGVWP-QATSEYGPFLRFTNNQQ 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	145/540 (27%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	64/209 (31%)
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	149/553 (27%)
		Aes	<146..345	CDD:223730	63/211 (30%)
		RILP-like	<677..>717	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467434
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950