DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and cel.1

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_955901.2	Gene:	cel.1 / 322481	ZFINID:	ZDB-GENE-030131-1201	Length:	550	Species:	Danio rerio

Alignment Length:	558	Identity:	166/558 - (29%)
Similarity:	248/558 - (44%)	Gaps:	107/558 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GSVKGR-RLSGI--YGDEFYSFEGIPFAKPPLGKARFVASQLADP-WNSELDARQERPIPLQMDR 108
            |.|:|: |..|:  |.|   :|:|||||.||   .|| ...:|.| |...|.....|...||::.
Zfish    30 GMVQGKSRSVGLFRYMD---TFKGIPFAAPP---KRF-EKPVAHPGWEGVLKTTDYRKRCLQLNL 87

  Fly   109 RSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRD------- 166
            .:..|:|||||||||::..........|||||:||||||..||...:.:..:||...:
Zfish    88 LATDVIGSEDCLYLNIWVPQGRTVSSNLPVMVFIYGGAFLLGGGQGANFLDNYLYDGEEMADRGN 152

  Fly   167 VVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAA 231
            |:.|.||||:.:|||:|  :|...:|||.||.||..|:.||.::|:.|.|:|.||||||||||||
Zfish   153 VIVVTFNYRVGALGFMS--TGDDGIPGNYGLWDQHAAISWVHRNIKAFGGNPDNITLFGESAGAA 215

  Fly   232 SVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPI----LEFL 292
            ||:|.:..|:.||:..:||..||..|.||..:.:.......:||..|       .||    .:.|
Zfish   216 SVNFQIITPKNKGMIRRAISQSGVALCPWAISRNPRQFAEEIATKVG-------CPIDSGMADCL 273

  Fly   293 RNVN--AEKLIGHDFISPRDRCFGFLNPFAPVVGGLVAAPF----------QQLMKEAWSCEVPL 345
            :..:  |..|.|...::.        :|.||:|..|..:|.          :.|...|  .::..
Zfish   274 KRADPKAVTLAGKLKLTS--------SPDAPIVHNLYLSPVIDGDFIPDEPETLFGNA--ADIDY 328

  Fly   346 LLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPRGI 410
            :.|....:..:   |..:|...:...|...|             |||....|..|.:......||
Zfish   329 IAGVNDMDAHI---FATIDIPSINNALTTTP-------------VEEVQALATALSRDRGQDAGI 377

  Fly   411 --------------TKSNITQ-ILDLFSYKLFWHGIHRVVLSRLSHAQ-APTYLYRFDFDSPKLN 459
                          .|..:.| :::|.:..:|.......:.....:|: |.|:.|.|. :|.::.
Zfish   378 ATFQEYTVNWGDKPNKEKVKQTVVELETDYMFLVPTQAALYLHTDNAKSARTFSYLFT-ESSRIP 441

  Fly   460 LMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQPLD-SPEFLTIQR-MVGILTTFARTGDPNCPE 522
            :.       .:..|..|||:|.|:|.|....  ||. .|....:.: |:...:.||:|||||..|
Zfish   442 VF-------PLWMGADHADELQYVFGKPFAT--PLGYFPRHRDVSKYMIAYWSNFAQTGDPNKGE 497

  Fly   523 TG-PDPWMPVSTKSPFKALNIGQQ-VECVTQVEKDGLK 558
            :. |..|...|        |.|.| ::...::.|:.:|
Zfish   498 SKVPVTWPEFS--------NPGHQYLDINNKMNKNNVK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	161/531 (30%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	78/204 (38%)
cel.1	NP_955901.2	COesterase	25..517	CDD:306613	164/546 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575564
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750