DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Ces2i

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_008758816.2	Gene:	Ces2i / 292152	RGDID:	1565045	Length:	558	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	151/552 - (27%)
Similarity:	236/552 - (42%)	Gaps:	88/552 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKCFRFLILRCCPGFKRFSCQSAGDADSKVVKLSVGSVKGRRL------SGIYGDEFYSFEGIPF 71
            :.|...|:|:...|         .|:.|.:.....|.|:|..:      ||:     ::|.||||
  Rat    13 VACGLLLLLQHVHG---------QDSASPIRNTQTGQVRGSFVHVKDTKSGV-----HTFLGIPF 63

  Fly    72 AKPPLGKARFVASQLADPWNSELDARQERPIPLQMDRRSGKVVG-----------SEDCLYLNVY 125
            ||||:|...|...:..:||:...|...:..:.||.|......:.           ||||||||:|
  Rat    64 AKPPVGPLHFAPPEDPEPWSGVRDGTSQPDMCLQTDIMKEDFIKEMKLTMHPTPMSEDCLYLNIY 128

  Fly   126 TKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLD 190
            |.........|||||:|:||....|.| ..........:.::|.|...|||..|||.|  :|...
  Rat   129 TPAHAREGSNLPVMVWIHGGGLVLGSA-SMNVASTLAATEEIVIVAIQYRLGILGFFS--TGDEH 190

  Fly   191 VPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGS 255
            ..||.|..||:.||.||.|:|..|.|:...:|:||.|||..||...:..|.:|||||.|||.||.
  Rat   191 ARGNWGYLDQVAALCWVQQNIAYFGGNHGKVTIFGVSAGGTSVSSHVVSPMSKGLFHGAIMQSGV 255

  Fly   256 MLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFA 320
            .|.|.:.:..|:.::..:|..:|.|....|. ::..||..:.::::.             :|...
  Rat   256 ALLPDLISDTSEVVYKTVANLSGCEASDSEA-LIRCLRAKSKQEILA-------------INQVF 306

  Fly   321 PVVGGLVAAPF-----QQLMKEAWSCEVPLLLGGTSFE-GLVYYPFCQLDNGYMLELLKHEPAMV 379
            .::.|:|...|     |:|:.......||.::|..:.| ||....|..||:     ::|......
  Rat   307 KMIPGVVDGKFLPKHPQELLASGDFHPVPSIIGVNTDECGLGVPMFMGLDH-----IIKKITRDT 366

  Fly   380 LPHELYQSMSVEERNTAA---------DVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVV 435
            ||..|        ::|||         |::::.:.|.....::...|..::....:|  .|..:.
  Rat   367 LPTVL--------KSTAAQMMLPPECIDLIMEEYMGDTEDPETLQEQFKEMLGDFMF--VIPALE 421

  Fly   436 LSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQ-PLDSPEF 499
            ::....:|||.|.|.|.    .|.....|:....:|..  |.||:.::|........ .:...|.
  Rat   422 VAHFQRSQAPVYFYEFQ----HLPSFIKQVRPSHVKAD--HGDDILFVFSSYFWGMNFDITEEEE 480

  Fly   500 LTIQRMVGILTTFARTGDPNCPETGPDPWMPV 531
            |..:|::.....|||.|:||..:.   |:.||
  Rat   481 LLKRRVMKYWANFARNGNPNSEDL---PYWPV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	147/530 (28%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	62/191 (32%)
Ces2i	XP_008758816.2	COesterase	30..537	CDD:395084	146/526 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336241
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840