DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Ces2g

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001099645.1	Gene:	Ces2g / 291952	RGDID:	1308358	Length:	560	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	165/579 - (28%)
Similarity:	245/579 - (42%)	Gaps:	126/579 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SKVVKLSVGSVKGRRL------SGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQ 98
            |.:.....|.|:|:..      ||:     ::|.||||||.|:|..||...:..:||:...|...
  Rat    33 SPIRNTHTGQVQGKLTHSKDFKSGV-----HTFLGIPFAKAPVGPLRFAPPEAPEPWSGVRDGTS 92

  Fly    99 ER---PIPLQMDRRSGK--------VVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGA 152
            :.   |..::|:....|        |..||||||||:|..........|||||:|:|||...|.|
  Rat    93 QSNICPQNVRMNMEGLKEMKLTLPPVSMSEDCLYLNIYAPAHAHEGSHLPVMVWIHGGALTVGMA 157

  Fly   153 VKSKY-GPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNG 216
              |.| |.....:.|||.|...|||..|||.|  :|.....||.|..||:.||:||.|:|.:|.|
  Rat   158 --SMYDGSMLAATEDVVVVTIQYRLGVLGFFS--TGDHHARGNWGYLDQVAALRWVQQNIAHFGG 218

  Fly   217 DPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYE- 280
            :|..:|:||||||..||...:..|.:|||||:|||.||..|.|......|:.::..:...:|.|
  Rat   219 NPDCVTIFGESAGGLSVSSHVVSPMSKGLFHRAIMESGVALMPGTIFNFSEMVYQMVVKLSGCEA 283

  Fly   281 -----------GPAEE-----------VPIL---EFLRNVNAEKLIGHDFISPRDRCFGFLNPFA 320
                       |.:||           :|.:   |||.|...|.|...||           :|..
  Rat   284 MDPESLVHCLRGKSEEQITVISKEFQMIPAVVDGEFLPNHPQELLASADF-----------HPVP 337

  Fly   321 PVVGGLVAAPFQQLMKEAWSCEVPLLLG------GTSFEGLVYYPFCQLDNGYMLELLKHEPAMV 379
            .::|         ...:.:...||.::|      |.:.|.|..:            |....|.|:
  Rat   338 SIIG---------FNNDEYGWIVPKVIGSAQTIKGITRENLQAF------------LKDTAPQMM 381

  Fly   380 LPHELYQSMSVEERNTAADVLVKYHYG----PRGITKSNITQILDLFSYKLFWHGIHRVVLSRLS 440
            ||.|            .:|:|::.:.|    |:.: ::..|::::.|.:.     |..:.::|..
  Rat   382 LPPE------------CSDLLMEEYMGDIEDPQTL-QAQFTEMMEDFMFV-----IPSLQVARFQ 428

  Fly   441 HAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQA-KQPLDSPEFLTIQR 504
            .:.||.|.|.|...|..|..:|......|      |.|::.::|...... |..|...|.|..:|
  Rat   429 RSHAPVYFYEFQHQSSFLKDIRPPHVKAD------HGDEVPFVFGSFFWGMKLNLTEGEKLLNRR 487

  Fly   505 MVGILTTFARTGDPNCPETGPDPWMPV-STKSPFKALNIGQQVECVTQVEKDGLKVWNR 562
            |:.....|||.|:||   :...|:.|| .....:..||....|..:.:..|  |:.|.:
  Rat   488 MMKYWANFARYGNPN---SNSLPYWPVFDYDEQYLQLNTQPAVGRIQKARK--LQFWTK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	159/549 (29%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	78/218 (36%)
Ces2g	NP_001099645.1	COesterase	31..539	CDD:278561	164/575 (29%)
Ces2g	NP_001099645.1	Aes	<129..>232	CDD:223730	47/106 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740