Protein Alignment alpha-Est6 and CES4A

DIOPT Version :9

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 165/614 - (26%)
• Similarity: 256/614 - (41%)
• Gaps: 150/614 - (24%)

  Fly    48 GSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDA---------------- 96
            |:::|:::. :.......|.|:||::||||..||...:..:||....||
Human    57 GTLQGKQMH-VGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLALSPGWS 120

  Fly    97 --RQER--------------PIPLQ------MDRRSGKVVG--------------SEDCLYLNVY 125
              .:.|              |.||.      :....|::..              ||||||||||
Human   121 AVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFSEDCLYLNVY 185

  Fly   126 TKHFNESEPPLPVMVYIYGGAFRTGGAVKSKY-GPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKL 189
            .......:|.|||||:..||||..|.|  |.| |.|......||.|...:||...|||.. .|:.
Human   186 APARAPGDPQLPVMVWFPGGAFIVGAA--SSYEGSDLAAREKVVLVFLQHRLGIFGFLRW-RGRT 247

  Fly   190 D---VPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIM 251
            |   ..||.||.||:.||:||.::|..|.|||.|:||||:||||.|:..:|..|.|.||||:||.
Human   248 DDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAIS 312

  Fly   252 MSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFL 316
            .||:.|.......:...:..::|..||....:.:: ::..||.::..|::.   :|.:.| |..|
Human   313 QSGTALFRLFITSNPLKVAKKVAHLAGCNHNSTQI-LVNCLRALSGTKVMR---VSNKMR-FLQL 372

  Fly   317 N----------PFAPVVGGLVAA--PFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYML 369
            |          ..:|||.|:|..  |. .|:.:.....||.|||..:.|.....|       |::
Human   373 NFQRDPEEIIWSMSPVVDGVVIPDDPL-VLLTQGKVSSVPYLLGVNNLEFNWLLP-------YIM 429

  Fly   370 ELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPR---GITKSNITQILDLF-------SY 424
            :...:..||                 ..:.:.|..:..|   .|||..:..:::.:       .:
Human   430 KFPLNRQAM-----------------RKETITKMLWSTRTLLNITKEQVPLVVEEYLDNVNEHDW 477

  Fly   425 KLFWHGIHRVVLS--------RLSH----AQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHA 477
            |:..:.:..:|..        :.:|    |..|.|||.|:..:..: :::.:..|.|      |.
Human   478 KMLRNRMMDIVQDATFVYATLQTAHYHRDAGLPVYLYEFEHHARGI-IVKPRTDGAD------HG 535

  Fly   478 DDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPDPWMPVSTKSPFKALNI 542
            |::.::|.........:...:.|::| |:.....|||||:||   .|..|..|...|.. |.|
Human   536 DEMYFLFGGPFATGLSMGKEKALSLQ-MMKYWANFARTGNPN---DGNLPCWPRYNKDE-KYL-- 593

  Fly   543 GQQVECVTQVEKDGLKV-------WNRLY 564
              |::..|:|   |:|:       |..||
Human   594 --QLDFTTRV---GMKLKEKKMAFWMSLY 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	154/575 (27%)
		Aes	<133..325	CDD:223730	77/205 (38%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	162/608 (27%)
		Aes	<184..>291	CDD:223730	50/109 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800