DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Tg

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	159/622 - (25%)
Similarity:	237/622 - (38%)	Gaps:	201/622 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQER---- 100
            |:|||:           |....:.|.|.|:|:|.|||.:.||.|.::.: |....||.:.|
  Rat  2214 SQVVKV-----------GTAWKQVYQFLGVPYAAPPLAENRFQAPEVLN-WTGSWDATKLRSSCW 2266

  Fly   101 ------PIPLQMDRRSGKVVGSEDCLYLNVYTKH---FNESEPPLPVMVYIY--------GGAFR 148
                  |.|.|:         |||||||||:...   .|.|     |:|:.:        ||...
  Rat  2267 QPGTRTPTPPQI---------SEDCLYLNVFVPENLVSNAS-----VLVFFHNTVEMEGSGGQLN 2317

  Fly   149 TGGAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRN 213
            ..|::.:..|       :::.|..||||...||||  ||..:|.||.||.||:.||.||..||..
  Rat  2318 IDGSILAAVG-------NLIVVTANYRLGVFGFLS--SGSDEVAGNWGLLDQVAALTWVQTHIGA 2373

  Fly   214 FNGDPQNITLFGESAGA--ASVHFMMCLPQAKGLFHKAIMMSGSMLSP-WVNAPDSDGIFCRLAT 275
            |.||||.:||..:..||  ||:|.::..|....||.||::|.||.||| .:.:||      |...
  Rat  2374 FGGDPQRVTLAADRGGADVASIHLLITRPTRLQLFRKALLMGGSALSPAAIISPD------RAQQ 2432

  Fly   276 SAGYEGPAEEV--PILEFLRNVNAEKLIGHDFISPRDRCF-----GFLN-----------PF--- 319
            .|.  ..|:||  |      |.:.::::.         ||     ..||           ||
  Rat  2433 QAA--ALAKEVGCP------NSSVQEVVS---------CFRQKPANILNEAQTKLLAVSGPFHYW 2480

  Fly   320 APVVGG--LVAAPFQQLMKEAWSCEVPLLLGGTSFEGLV---------------------YYPFC 361
            .|||.|  |...|.::| |.....:|.||:||:..:||:                     :|...
  Rat  2481 GPVVDGQYLRELPSRRL-KRPLPVKVDLLIGGSQDDGLINRAKAVKQFEESQGRTNSKTAFYQAL 2544

  Fly   362 QLDNG---------------YMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPRGIT 411
            |...|               |.||   |..      :.|.|.|....|...|..:
  Rat  2545 QNSLGGEDSDARILAAAIWYYSLE---HST------DDYASFSRALENATRDYFI---------- 2590

  Fly   412 KSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCH 476
               |..|:::.|   .|        :|.:......|.....:....|.|:.:          |.:
  Rat  2591 ---ICPIVNMAS---LW--------ARRTRGNVFMYHVPESYGHGSLELLAD----------VQY 2631

  Fly   477 ADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPD-------PW---MPV 531
            |  .|..|:...|....::. :.|:: :::...:.|.|:|:||.|.....       ||   :|.
  Rat  2632 A--FGLPFYSAYQGYFSMEE-QSLSL-KVMQYFSNFIRSGNPNYPHEFSQKAAEFATPWPDFVPG 2692

  Fly   532 STKSPFKALNIGQQVECVTQVEKDGLKVWNRLYSDLK 568
            :....:|.|:  .|:.....::|.....|::....||
  Rat  2693 AGGESYKELS--AQLPNRQGLKKADCSFWSKYIQTLK 2727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	152/586 (26%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	71/223 (32%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		159/622 (26%)
		COesterase	2198..2719	CDD:278561	156/612 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336495
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930