DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Ces2a

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	160/555 - (28%)
Similarity:	243/555 - (43%)	Gaps:	94/555 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKCFRFLILRCCPGFKRFSCQSAGDADSKVVKLSVGSVKGRRL------SGIYGDEFYSFEGIPF 71
            :.|...|:|:...|         .|:.|.:.....|.|:|..:      |||     ::|.||||
  Rat    13 VACGLLLLLQHVHG---------QDSASPIRNTHTGQVRGSFVHVKDTKSGI-----HTFLGIPF 63

  Fly    72 AKPPLGKARFVASQLADPWNSELDARQERPIPLQMDRRSGKVVG-----------SEDCLYLNVY 125
            ||||:|..||...:..:||:...||..:..:.||.|..:...:.           ||||||||:|
  Rat    64 AKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIY 128

  Fly   126 TKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLD 190
            |.........|||||:|:||....|.|..:. ......:.::|.|...|||..|||.|  :|..:
  Rat   129 TPAHAREGSNLPVMVWIHGGGLVLGSASMND-ASTLAATEEIVIVSIQYRLGVLGFFS--TGDQN 190

  Fly   191 VPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGS 255
            ..||.|..||:.||:||.|:|..|.|:...:|:||.|||..||...:..|.:|||||.|||.||.
  Rat   191 ARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGV 255

  Fly   256 MLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFA 320
            .|.|.:.:..|:.::..:|..:|.|.|..|. ::..||..:.::::.             :|...
  Rat   256 ALLPDLISDKSEVVYKTVANLSGCEAPDSEA-LIRCLRAKSKQEILA-------------INQVF 306

  Fly   321 PVVGGLVAAPF-----QQLMKEAWSCEVPLLLGGTSFE-GLVYYPFCQLDNGYMLELLKHEPAMV 379
            .::.|:|...|     |:|:.......||.::|..:.| |.....|..||:     ::|......
  Rat   307 KMIPGVVDGKFLPKHPQELLASGDFHPVPSIIGINTDECGWGIPVFLGLDH-----IIKKITRET 366

  Fly   380 LPHELYQSMSVEERNTAA---------DVLVKYHYGPRGITKSNITQILDLFSYKL--FWHGIHR 433
            ||..|        ::|||         |::::.:.|    ...|...:.:.|.:.|  |...|..
  Rat   367 LPTVL--------KSTAAQMMLPPECIDLIMEEYMG----DTENPETLQEQFRHMLGDFMFVIPA 419

  Fly   434 VVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQ-PLDSP 497
            :.::....:|||.|.|.|.    .|.....|:....:|..  |.||:.::|........ .|...
  Rat   420 LQVAHFQRSQAPVYFYEFQ----HLPSFIKQVRPSHVKAD--HGDDILFVFGSYLWGMTFDLTEE 478

  Fly   498 EFLTIQRMVGILTTFARTGDPNCPETGPD-PWMPV 531
            |.|..:|::.....|||||:||    |.| |..||
  Rat   479 EELLKRRVMKYWANFARTGNPN----GEDLPHWPV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	156/533 (29%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	63/191 (33%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	155/529 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840