DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and Ces1c

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	169/572 - (29%)
Similarity:	247/572 - (43%)	Gaps:	74/572 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LRCCPGFKRFSCQSAGDADSKVVKLSVGSVKGR--RLSGIYGDEFYSFEGIPFAKPPLGKARFVA 83
            |..||.:     .|...:...||..:.|.|.|:  .|.| :......|.|:||||||||..||..
  Rat    11 LAACPIW-----ASGHPSSPPVVDTTKGKVLGKYVSLEG-FTQPVAVFLGVPFAKPPLGSLRFAP 69

  Fly    84 SQLADPWNSELDARQERPIPLQMDRRSGKVVG--------------SEDCLYLNVYTKHFNESEP 134
            .:.|:||:...:.....|:..| |...||::.              ||||||||:|:........
  Rat    70 PEPAEPWSFVKNTTTYPPMCSQ-DGVVGKLLADMLSTGKENIPLEFSEDCLYLNIYSPADLTKNS 133

  Fly   135 PLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRD-VVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLH 198
            .|||||:|:||....|||  |.|....|.:.: ||.|...|||...|..|  :|.....||....
  Rat   134 RLPVMVWIHGGGLIIGGA--SPYSGLALSAHENVVVVTIQYRLGIWGLFS--TGDEHSRGNWAHL 194

  Fly   199 DQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNA 263
            |||.||:||..:|.||.|:|.::|:||||||..||..::..|.||.|||:||..||.:|:..::.
  Rat   195 DQLAALRWVQDNIANFGGNPDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVLTTNLDK 259

  Fly   264 PDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKL---IGHDFISPRDRCFGFLNPFAPVVGG 325
            .::..:...:||.:|....:....:....:...||.|   :..|..|......|.:.|..|
  Rat   260 KNTQAVAQMIATLSGCNNTSSAAMVQCLRQKTEAELLELTVKLDNTSMSTVIDGVVLPKTP---- 320

  Fly   326 LVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQ---LDNGYMLELLKHEPAMVLPHELYQS 387
                  ::::.|.....||.::|....|.....|...   |..|.|.|.:    |..|......:
  Rat   321 ------EEILTEKSFNTVPYIVGFNKQEFGWIIPTMMGNLLSEGRMNEKM----ASSLLRRFSPN 375

  Fly   388 MSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSR-LSHAQAPTYLYRF 451
            :::.|....| ::.||..|.....|.. ..:||:||...|  ||..|::|| |..|.||||:|.|
  Rat   376 LNISESVIPA-IIEKYLRGTDDPAKKK-ELLLDMFSDVFF--GIPAVLMSRSLRDAGAPTYMYEF 436

  Fly   452 DFDSPKLNLMRNQLCGDDIKRGVCHADDL----GYIFHKQAQAKQPLDSPEFLTIQRMV-GILTT 511
            .:....::..|.|....|      |.|::    |..|.|:..      |.|...:.::| .....
  Rat   437 QYRPSFVSDQRPQTVQGD------HGDEIFSVFGTPFLKEGA------SEEETNLSKLVMKFWAN 489

  Fly   512 FARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQVECVTQVEKDGLKVWNRL 563
            |||.|:||  ..|...|.....|..:  |.||...:...:::.:.:..|..|
  Rat   490 FARNGNPN--GEGLPHWPEYDQKEGY--LQIGATTQQAQKLKGEEVAFWTEL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	159/527 (30%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	68/195 (35%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	163/549 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820