Protein Alignment alpha-Est6 and CES3

DIOPT Version :9

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 170/603 - (28%)
• Similarity: 253/603 - (41%)
• Gaps: 127/603 - (21%)

  Fly    20 ILRCCPGFKRFSCQSAGDADSKVVKLSVGSVKGRRLSGIYG-DEFYS-FEGIPFAKPPLGKARFV 82
            :|..||     :..:..:.....|..::|.|:||:: |:.| |...: |.|||||:||||..||.
Human    18 LLLACP-----ATATGPEVAQPEVDTTLGRVRGRQV-GVKGTDRLVNVFLGIPFAQPPLGPDRFS 76

  Fly    83 ASQLADPWNSELDARQERPIPLQ--MDRRSGKVV---------GSEDCLYLNVYTKHFNESEPPL 136
            |...|.||....||....|:.||  ....|.:.|         .|||||.||||    :.:|.|.
Human    77 APHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVY----SPAEVPA 137

  Fly   137 ----PVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDV 191
                ||||:::|||..||      |:..:.||       |||.|...|||..|||.|  :|....
Human   138 GSGRPVMVWVHGGALITGAATSYDGSALAAYG-------DVVVVTVQYRLGVLGFFS--TGDEHA 193

  Fly   192 PGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSM 256
            |||.|..|.:.||:||.::|..|.||...:|:||.|||.:.:..::..|.|.||||:||..||.:
Human   194 PGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVI 258

  Fly   257 LS-------PWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFG 314
            .:       ||   |.:..|...||.|:  ..|||   :::.|:....|:|:    :|.:
Human   259 TTPGIIDSHPW---PLAQKIANTLACSS--SSPAE---MVQCLQQKEGEELV----LSKK----- 306

  Fly   315 FLNPFAPV-VGGLV--AAPFQQLMKEAWSCEVPLLLG--GTSFEGLVYYPFCQLDNGYMLELLKH 374
            ..|...|: |.|.|  .:| ::|:||.....||.|:|  ...|..|:...:..||.   :|.:..
Human   307 LKNTIYPLTVDGTVFPKSP-KELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDT---MEQMSR 367

  Fly   375 EPAMVL----------PHELYQSMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWH 429
            |..:.:          |.|:..::..|...:.:|...|             .|....|...:|.:
Human   368 EDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAK-------------CQAFQEFMGDVFIN 419

  Fly   430 GIHRVVLSR-LSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQ--AQAK 491
             :..|..|| |..:.:|.:.|.|.........::......|      |..:..::|...  ....
Human   420 -VPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKAD------HGAEGAFVFGGPFLMDES 477

  Fly   492 QPLDSPEFLTIQRMVGIL-----TTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQVECVTQ 551
            ..|..||....::.:.:.     |.||||||||.....|.|           ..|..:|...:..
Human   478 SRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWP-----------QFNQAEQYLEINP 531

  Fly   552 VEKDGLK---VWNRLYSD 566
            |.:.|.|   .|.:.:|:
Human   532 VPRAGQKFREAWMQFWSE 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	160/551 (29%)
		Aes	<133..325	CDD:223730	72/209 (34%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	166/580 (29%)
		Aes	<129..>247	CDD:223730	49/130 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790