DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and Ces2c

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	531	Identity:	148/531 - (27%)
Similarity:	221/531 - (41%)	Gaps:	106/531 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GSVKGRRL------SGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWN-------------SE 93
            |.::|..:      :|:     ::|.||||||||:|..||...:..:||:             ..
Mouse    41 GQIQGSLIHVKDTKAGV-----HTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQN 100

  Fly    94 LDARQERPIPLQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYG 158
            ||...|..:| .|.........||||||||:||.........|||||:|:|||...|.|  |.:.
Mouse   101 LDMLNEAGLP-DMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMA--SMFD 162

  Fly   159 PDYL-MSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNIT 222
            ...| ::.|:|.|...|||..|||.|  :|.....||.|..||..||:||.|:|.:|.|:|..:|
Mouse   163 GSLLTVNEDLVVVTIQYRLGVLGFFS--TGDQHARGNWGYLDQAAALRWVQQNIAHFGGNPDRVT 225

  Fly   223 LFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYE------- 280
            :||||||..||...:..|.::||||.|||.||..|.|.:.:..|:.:...:|..:|.|
Mouse   226 IFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVALLPDLISETSEMVSTTVAKLSGCEAMDSQAL 290

  Fly   281 -----GPAEE-----------VPIL---EFLRNVNAEKLIGHDFISPRDRCFGFLNPFAPVVGGL 326
                 |.:|.           :|.:   ||......|.|...||           :|...::|
Mouse   291 VRCLRGKSEAEILAINKVFKMIPAVVDGEFFPRHPKELLASEDF-----------HPVPSIIG-- 342

  Fly   327 VAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVE 391
                   :..:.:...:|:::|.           .|:..|...|.|:    .||.....|.|...
Mouse   343 -------VNNDEFGWSIPVVMGS-----------AQMIKGITRENLQ----AVLKDTAVQMMLPP 385

  Fly   392 ERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSP 456
            |   .:|:|::.:.|.....::...|..::....:|  .|..:.::....:.||.|.|.|.....
Mouse   386 E---CSDLLMEEYMGDTEDAQTLQIQFTEMMGDFMF--VIPALQVAHFQRSHAPVYFYEFQHPPS 445

  Fly   457 KLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQA-KQPLDSPEFLTIQRMVGILTTFARTGDPNC 520
            ....:|......|      |||::.::|...... |......|.|..:||:.....|||.|:||.
Mouse   446 YFKDVRPPHVKAD------HADEIPFVFASFFWGMKLDFTEEEELLSRRMMKYWANFARHGNPNS 504

  Fly   521 PETGPDPWMPV 531
            ...   |:.||
Mouse   505 EGL---PYWPV 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	148/531 (28%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	73/218 (33%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	148/531 (28%)
		Aes	<130..>233	CDD:223730	46/106 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740