Protein Alignment alpha-Est6 and NLGN1

DIOPT Version :10

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 628
• Identity: 162/628 - (25%)
• Similarity: 240/628 - (38%)
• Gaps: 164/628 - (26%)

  Fly    33 QSAGDADSKVVKLSVGSVKG--RRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELD 95
            |...|.| .:|..:.|.::|  :.|:.........|.|:|:|.||.|:.||...:...||:...:
Human    46 QKLDDVD-PLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRN 109

  Fly    96 ARQERPIPLQ--MDRRSGKVV------------------GSEDCLYLNVYT-------------- 126
            |.|..|:..|  :|.|..:|:                  .||||||||:|.
Human   110 ATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDD 174

  Fly   127 ---------KHFNESEPPLPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFNYRL 176
                     :...:|..|.||||||:||::..|      |:|.:.||       :|:.:..||||
Human   175 LGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYG-------NVIVITVNYRL 232

  Fly   177 CSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMC--- 238
            ..|||||  :|.....||.||.|.:.||:|.|::|..|.|||..||:||..||.:.|:.:..
Human   233 GVLGFLS--TGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHY 295

  Fly   239 ------LPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNA 297
                  ....||||.:||..||:.||.|..:.........|||..|. ..::.|.::|.|:....
Human   296 SEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGC-NVSDTVELVECLQKKPY 359

  Fly   298 EKLIGHDFISPRDRCFGFLNPFAPVV-GGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYP-F 360
            ::|:..|....|     :...|.||: |.::....|.||::.......::||....|||.:.. .
Human   360 KELVDQDIQPAR-----YHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENI 419

  Fly   361 CQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYG-PRG--ITKSNI------- 415
            ...|:|                     :|..:.:.|....|...|| |.|  :.:..|
Human   420 VDSDDG---------------------ISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDW 463

  Fly   416 ----------TQILDLFSYKLFWHGIHRVVLSRLSHAQ------APTYLYRFDFDSPKLNLMRNQ 464
                      ..:|.||:       .|:.|...::.|.      :|||.|.|           ..
Human   464 ADRHNPETRRKTLLALFT-------DHQWVAPAVATADLHSNFGSPTYFYAF-----------YH 510

  Fly   465 LCGDD---IKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGIL-----TTFARTGDPNCP 521
            .|..|   ......|.|::.|:..........|....|.....|:..:     |.||:|||||.|
Human   511 HCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP 575

  Fly   522 ETGPDPWMPVSTKSPFKALNIGQQVECVTQVEKD------GLK 558
                   :|..||......|..::|......:||      |||
Human   576 -------VPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLK 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	153/592 (26%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	160/622 (26%)