Protein Alignment alpha-Est6 and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 156/588 - (26%)
• Similarity: 242/588 - (41%)
• Gaps: 156/588 - (26%)

  Fly    38 ADSKVVKLSVGSVKGRRL---SGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQE 99
            |...||..:.|.::|.|.   |.|.| ....:.|:|:|.||.|:.||...:....|....:|.|.
Human    43 AQYPVVNTNYGKIQGLRTPLPSEILG-PVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQF 106

  Fly   100 RPI-PLQMDRR-------------------SGKVVGSEDCLYLNVYT------------------ 126
            ..: |..:|.|                   :.....:|||||||:|.
Human   107 SAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSN 171

  Fly   127 -----KHFNESEPPLPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFNYRLCSLG 180
                 |..:|.....||||||:||::..|      |::.:.||       :|:.:..||||..||
Human   172 DHGEDKDIHEQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYG-------NVIVITINYRLGILG 229

  Fly   181 FLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGL 245
            |||  :|.....||.||.||:.||:|:.:::..|.|||:.:|:||..|||:.|..:.....::||
Human   230 FLS--TGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGL 292

  Fly   246 FHKAIMMSGSMLSPW-VNAPD-------SDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIG 302
            |.|||:.||:.||.| ||...       :|.:.|.:         .:...::|.|:|.|.::||
Human   293 FQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNM---------LDTTDMVECLKNKNYKELI- 347

  Fly   303 HDFISPRDRCFGFLNPFAPVV-GGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNG 366
            ...|:|..    :...|.||: |.::....|.||::.......::||....|||.:     :|.
Human   348 QQTITPAT----YHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKF-----VDG- 402

  Fly   367 YMLELLKHEPAMVLPHELYQSMS---------VEERNTAADVLVKYHY-------GPRGITKSNI 415
                ::.:|.. |.|::...|:|         .|.::|..:. :|:.|       .|....|:.:
Human   403 ----IVDNEDG-VTPNDFDFSVSNFVDNLYGYPEGKDTLRET-IKFMYTDWADKENPETRRKTLV 461

  Fly   416 TQILDLFSYKLFWHGIHRVVLSRLS----HAQ--APTYLYRFDFDSPKLNLMRNQLCGDDIK--- 471
            ....|           |:.|...::    |||  :|||.|.|           ...|..::|
Human   462 ALFTD-----------HQWVAPAVATADLHAQYGSPTYFYAF-----------YHHCQSEMKPSW 504

  Fly   472 RGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGIL-----TTFARTGDPNCPETGPDPWMPV 531
            ....|.|::.|:|.........|.|..|.....|:..:     |.||:|||||.|       :|.
Human   505 ADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP-------VPQ 562

  Fly   532 STK 534
            .||
Human   563 DTK 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	155/587 (26%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	155/587 (26%)