Protein Alignment alpha-Est6 and CES5A

DIOPT Version :9

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 172/605 - (28%)
• Similarity: 266/605 - (43%)
• Gaps: 140/605 - (23%)

  Fly     1 MWKLC-----QPRSRSRIKCFRFLILRCCPGFKRFSCQSAG-DADSKVVKLSVGSVKGRRLSGIY 59
            ||:||     .|.| |.:...|..:|       .::.:..| .|:.......:|.::|:::: :.
Human    22 MWRLCLVYYFYPAS-STLYVLRIDVL-------NYTSKDEGPSAEGPQRNTRLGWIQGKQVT-VL 77

  Fly    60 GD--EFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIPLQ------MDRRSGKV--- 113
            |.  ....|.|:|||.||||..||...|.|.||::..:|.....:.||      :|:...||
Human    78 GSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYP 142

  Fly   114 -VG-SEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYV 170
             .| ||||||||:|.....::...|||:|:..||||:||      |:..:.|       .||:.|
Human   143 KFGVSEDCLYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSASIFDGSALAAY-------EDVLVV 200

  Fly   171 LFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHF 235
            :..|||...||.:  :.....|||....||:.||.||.::|..|.|||.::|:|||||||.||..
Human   201 VVQYRLGIFGFFT--TWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSS 263

  Fly   236 MMCLPQAKGLFHKAIMMSGSMLSPWVNAPD---SDGI-----FCRLATSAGYEGPAEEVPILEFL 292
            ::..|.||||||||||.||..:.|::.|.|   |:.:     ||.       ...::...:|..|
Human   264 LILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFCG-------NNASDSEALLRCL 321

  Fly   293 RNVNAEKLIGHDFISPRDRCFGFLNPFAPVVGG--LVAAPFQQLMKEAWSCEVPLLLGGTSFEGL 355
            |...:::|:   .:|.:.:      .|..||.|  ....|...|.::|:.. :|.::|
Human   322 RTKPSKELL---TLSQKTK------SFTRVVDGAFFPNEPLDLLSQKAFKA-IPSIIG------- 369

  Fly   356 VYYPFCQLDNGYMLELLKHEPAMVLP-HELYQSMSVEERNTAADVLVK-YHYGPRGI-------- 410
                   ::|        ||...:|| .|..:.:|...::.|..::.. .|..|:.:
Human   370 -------VNN--------HECGFLLPMKEAPEILSGSNKSLALHLIQNILHIPPQYLHLVANEYF 419

  Fly   411 -TKSNITQI----LDLFSYKLFWHGIHRVVLSRLSH-AQAPTYLYRFDFDSPKLNLMRNQLCGDD 469
             .|.::|:|    |||.....|  .:..::.:|... |.||.|.|.|         .....|.:|
Human   420 HDKHSLTEIRDSLLDLLGDVFF--VVPALITARYHRDAGAPVYFYEF---------RHRPQCFED 473

  Fly   470 IKRGVC---HADDLGYIFHKQAQAK------QPLDSPEFLTIQRMVGILTTFARTGDPNCPETGP 525
            .|....   |||::.::| ..|..|      :.....|.|..::|:....||||||:||    |.
Human   474 TKPAFVKADHADEVRFVF-GGAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPN----GN 533

  Fly   526 DPWMPVSTKSPFKALNIGQQ 545
            |       .|.:.|.|:.:|
Human   534 D-------LSLWPAYNLTEQ 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	159/553 (29%)
		Aes	<133..325	CDD:223730	71/205 (35%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	162/563 (29%)
		Aes	<155..>258	CDD:223730	41/111 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142607
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790