DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and Tg

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_006520808.2	Gene:	Tg / 21819	MGIID:	98733	Length:	2767	Species:	Mus musculus

Alignment Length:	633	Identity:	157/633 - (24%)
Similarity:	232/633 - (36%)	Gaps:	195/633 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQER---- 100
            |:|:|:           |....:.|.|.|:|:|.|||...||.|.::.: |....||.:.|
Mouse  2212 SQVIKV-----------GTAWKQVYRFLGVPYAAPPLADNRFRAPEVLN-WTGSWDATKPRASCW 2264

  Fly   101 ------PIPLQMDRRSGKVVGSEDCLYLNVYTKH---FNESEPPLPVMVYIY--------GGAFR 148
                  |.|.|:         :||||||||:...   .|.|     |:|:.:        ||...
Mouse  2265 QPGTRTPTPPQI---------NEDCLYLNVFVPENLVSNAS-----VLVFFHNTMEMEGSGGQLT 2315

  Fly   149 TGGAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRN 213
            ..|::.:..|       :.:.|..||||...||||  ||..:|.||.||.||:.||.||..||..
Mouse  2316 IDGSILAAVG-------NFIVVTANYRLGVFGFLS--SGSDEVAGNWGLLDQVAALTWVQSHIGA 2371

  Fly   214 FNGDPQNITLFGESAGA--ASVHFMMCLPQAKGLFHKAIMMSGSMLSP-WVNAPD-SDGIFCRLA 274
            |.||||.:||..:.:||  ||:|.::..|....||.||::|.||.||| .:.:|: :......||
Mouse  2372 FGGDPQRVTLAADRSGADVASIHLLISRPTRLQLFRKALLMGGSALSPAAIISPERAQQQAAALA 2436

  Fly   275 TSAGYEGPAEEV-PILEFLRNVNAEKLIGHDFISPRDRCFGFLNPF---APVVGG--LVAAPFQQ 333
            ...|.  |...: .::..||...|..|  :|   .:.:......||   .|||.|  |...|.::
Mouse  2437 KEVGC--PTSSIQEVVSCLRQKPANIL--ND---AQTKLLAVSGPFHYWGPVVDGQYLRELPSRR 2494

  Fly   334 LMKEAWSCEVPLLLGGTSFEGLV---------------------YYPFCQLDNG----------- 366
            | |.....:|.||:||:..:||:                     :|...|...|
Mouse  2495 L-KRPLPVKVDLLIGGSQDDGLINRAKAVKQFEESQGRTNSKTAFYQALQNSLGGEDSDARILAA 2558

  Fly   367 ----YMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLF 427
                |.||   |..      :.|.|.|....|...|..:                |..:.:....
Mouse  2559 AVWYYSLE---HST------DDYASFSRALENATRDYFI----------------ICPMVNMASL 2598

  Fly   428 WHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQ 492
            |        :|.:......|.....:....|.|:.:          |.:|..|.:....|.|...
Mouse  2599 W--------ARRTRGNVFMYHVPESYGHGSLELLAD----------VQYAFGLPFYSAYQGQFST 2645

  Fly   493 PLDSPEFLTIQRMVGILTTFARTGDPNCPE-------TGPDPW---MPVSTKSPFKALNIG---- 543
            ...|.....:|    ..:.|.|:|:||.|.       ....||   :|.:....:|.|:..
Mouse  2646 EEQSLSLKVMQ----YFSNFIRSGNPNYPHEFSRKAAEFATPWPDFIPGAGGESYKELSAQLPNR 2706

  Fly   544 ---QQVEC---------------------VTQVEKDGLKVWNRLYSDL 567
               :|.:|                     :|:.|::.|:|...|..||
Mouse  2707 QGLKQADCSFWSKYIQTLKDAGNGAKDAQLTKSEEEDLEVGPGLEEDL 2754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	146/570 (26%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	68/207 (33%)
Tg	XP_006520808.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	301..359	CDD:238114
		TY	<612..658	CDD:238114
		TY	661..726	CDD:238114
		TY	730..>776	CDD:381826
		TY	<893..922	CDD:381826
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Ephrin_rec_like	1464..1509	CDD:311571
		TY	1519..1566	CDD:214561
		COesterase	2198..2717	CDD:365897	150/594 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832912
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930