DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est6 and Nlgn2

DIOPT Version :9

Sequence 1:NP_524262.1 Gene:alpha-Est6 / 40902 FlyBaseID:FBgn0015574 Length:568 Species:Drosophila melanogaster
Sequence 2:NP_001351066.1 Gene:Nlgn2 / 216856 MGIID:2681835 Length:836 Species:Mus musculus


Alignment Length:607 Identity:170/607 - (28%)
Similarity:249/607 - (41%) Gaps:117/607 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 PGFKRFSCQSAGDADSKVVKLSVGSVKG--RRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLA 87
            ||.......|.|:....||..:.|.|:|  |.|:.........|.|:|:|.||||..||...:..
Mouse    26 PGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAP 90

  Fly    88 DPWNSELDARQERP---------IPLQM------DRRSGKVV----GSEDCLYLNVY-------- 125
            ..|....:|....|         :|..|      |.......    .||||||||:|        
Mouse    91 ASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPL 155

  Fly   126 TKHFNES--EPP---------LPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFN 173
            ||..:|:  .||         .|||::::||::..|      |:|.:.||       :|:.|..|
Mouse   156 TKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVVTLN 213

  Fly   174 YRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMC 238
            |||..|||||  :|.....||.||.||:.||:|:|::|.:|.|||:.||:||..|||:.|:.::.
Mouse   214 YRLGVLGFLS--TGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLIL 276

  Fly   239 LPQAKGLFHKAIMMSGSMLSPW-VNAPDSDGIFCR-LATSAGYEGPAEEVPILEFLRNVNAEKLI 301
            ...::|||.|||..||:.:|.| ||.....  :.| ||...|.: ..:....:|.||..::.:|:
Mouse   277 SHHSEGLFQKAIAQSGTAISSWSVNYQPLK--YTRLLAAKVGCD-REDSTEAVECLRRKSSRELV 338

  Fly   302 GHDFISPRDRCFGFLNPFAPVV-GGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYY-PFCQLD 364
            ..|....|     :...|.||| |.:|....:.||::.......:|:|....|||.:. ...:.:
Mouse   339 DQDVQPAR-----YHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESE 398

  Fly   365 NGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVL---VKYHY---GPRGITKSNITQILDLFS 423
            :|..........:..:.: ||....      ..|||   :|:.|   ..|...:.....:|.||:
Mouse   399 DGVSASAFDFTVSNFVDN-LYGYPE------GKDVLRETIKFMYTDWADRDNGEMRRKTLLALFT 456

  Fly   424 YKLFWHGIHRVVLSRLSHA--QAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHK 486
            ... |  :...|.:...||  |:|.|.|.|        ....|..|........|.|:|.|:|..
Mouse   457 DHQ-W--VAPAVATAKLHADYQSPVYFYTF--------YHHCQAEGRPEWADAAHGDELPYVFGV 510

  Fly   487 QAQAKQPLDSPEFLTIQRMVGIL-----TTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQV 546
            .......|....|.....|:..:     |.||:|||||.|       :|..||......|..::|
Mouse   511 PMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP-------VPQDTKFIHTKPNRFEEV 568

  Fly   547 ECVTQVEKDGLKVWNRLYSDLK 568
                        ||::..|..|
Mouse   569 ------------VWSKFNSKEK 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est6NP_524262.1 COesterase 35..534 CDD:278561 159/561 (28%)
Aes <133..325 CDD:223730 73/209 (35%)
Nlgn2NP_001351066.1 COesterase 42..601 CDD:306613 166/591 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..661
Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354 679..699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 791..836
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832895
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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