Protein Alignment alpha-Est6 and Nlgn1

DIOPT Version :10

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 648
• Identity: 164/648 - (25%)
• Similarity: 241/648 - (37%)
• Gaps: 184/648 - (28%)

  Fly    33 QSAGDADSKVVKLSVGSVKG--RRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELD 95
            |...|.| .:|..:.|.::|  :.|:.........|.|:|:|.||.|:.||...:...||:...:
Mouse    46 QKLDDVD-PLVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRN 109

  Fly    96 ARQERPIPLQ--MDRRSGKVV------------------GSEDCLYLNVYT-------------- 126
            |.|..|:..|  :|.|..:|:                  .||||||||:|.
Mouse   110 ATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECAR 174

  Fly   127 ---------------KH--------------FNESEPPLPVMVYIYGGAFRTG------GAVKSK 156
                           ||              ..:|..|.||||||:||::..|      |:|.:.
Mouse   175 KPGKKICRKGGPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLAS 239

  Fly   157 YGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNI 221
            ||       :|:.:..||||..|||||  :|.....||.||.|.:.||:|.|::|..|.|||..|
Mouse   240 YG-------NVIVITVNYRLGVLGFLS--TGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRI 295

  Fly   222 TLFGESAGAASVHFMMC---------LPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSA 277
            |:||..||.:.|:.:..         ....||||.:||..||:.||.|..:.........|||..
Mouse   296 TVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKV 360

  Fly   278 GYEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFAPVV-GGLVAAPFQQLMKEAWSC 341
            |. ..::.|.::|.|:....::|:..|....|     :...|.||: |.::....|.||::....
Mouse   361 GC-NVSDTVELVECLQKKPYKELVDQDVQPAR-----YHIAFGPVIDGDVIPDDPQILMEQGEFL 419

  Fly   342 EVPLLLGGTSFEGLVYYP-FCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHY 405
            ...::||....|||.:.. ....|:|                     :|..:.:.|....|...|
Mouse   420 NYDIMLGVNQGEGLKFVENIVDSDDG---------------------VSASDFDFAVSNFVDNLY 463

  Fly   406 G-PRG--ITKSNI-----------------TQILDLFSYKLFWHGIHRVVLSRLSHAQ------A 444
            | |.|  :.:..|                 ..:|.||:       .|:.|...::.|.      :
Mouse   464 GYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFT-------DHQWVAPAVATADLHSNFGS 521

  Fly   445 PTYLYRFDFDSPKLNLMRNQLCGDD---IKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMV 506
            |||.|.|           ...|..|   ......|.|::.|:..........|....|.....|:
Mouse   522 PTYFYAF-----------YHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVML 575

  Fly   507 GIL-----TTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQVECVTQVEKD------GLK 558
            ..:     |.||:|||||.|       :|..||......|..::|......:||      |||
Mouse   576 SAVVMTYWTNFAKTGDPNQP-------VPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLK 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	155/612 (25%)
Nlgn1	XP_006535478.1	COesterase	52..646	CDD:395084	162/642 (25%)