DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and cest-30

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	578	Identity:	153/578 - (26%)
Similarity:	240/578 - (41%)	Gaps:	100/578 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DADSKVVKLSVGSVKGRRLSGIYGDEFY-SFEGIPFAKPPLGKARFVASQLADPWNSELDARQER 100
            :.:|:::....|.::|.......|.:.. .:.||||||.|:|..:|.....|:.|....|..:..
Worm    28 EKNSQILNAPCGPIRGNIYKHKNGTKIVDGYLGIPFAKAPVGALKFKKPVAAEKWTEPRDCYEYG 92

  Fly   101 PIPLQMDR------RSGKVVGSEDCLYLNVYTKHFNESEPP--LPVMVYIYGGAFRTGGAVKSKY 157
            |...|..|      :|......|:||.|||:...:..:|.|  |||:||||||.:..|   .:.|
Worm    93 PGCPQTGRFAALTAKSTAAFAEENCLTLNVFAPRWKLAEFPKGLPVLVYIYGGGYEIG---FTSY 154

  Fly   158 GPDYLMS-----RDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGD 217
            ..||.::     :||:.|..||||..||||::..|..:  ||.||.||.||||||..:|.:|.|:
Worm   155 MDDYSLTGTLPLKDVIVVTMNYRLGPLGFLTIADGIAN--GNYGLWDQTLALQWVQDNIASFGGN 217

  Fly   218 PQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAP-DSD-GIFCRLATSAGYE 280
            |:::||.|.||||.|..|:...|.:..||.::|.|||:....:...| |.: |:....|...||.
Worm   218 PESVTLSGTSAGATSTDFLSLSPHSNQLFQRSISMSGTAFCNFAIRPKDVEVGVCKEFAQFQGYT 282

  Fly   281 GPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLN------PFAP-VVGGLVAAPFQQLMKEA 338
            | .:...:.::....|..|.         ....||.:      ||.| ..|.....||..|.:||
Worm   283 G-TDSQSLFDWYMAQNVSKF---------KEVAGFQSTAAGAVPFIPNFDGDFFPKPFDILRREA 337

  Fly   339 WSCEV----------------PLLLGG-TSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQ 386
            ...:.                ||.... .:|||.:...:......|..::.|......|     :
Worm   338 PKKDALITVVTMESVGMIIFNPLFANAYNNFEGFINETYGPDVTDYYADVKKKLTGFYL-----K 397

  Fly   387 SMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRF 451
            .::..::.|..                  .:::|..|..:|..|....|.|.:.:.. ..||..|
Worm   398 DVNASDKATVN------------------RRVVDYVSDSVFNSGTLDAVKSYVKYGN-KVYLGSF 443

  Fly   452 DF--DSPK--LNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAK-QPLDSPEFLTIQRMVG-ILT 510
            ::  |:.|  :.||:.       .:...|:.|..|.|.....|. .|.|  |.:.:..|.| ::.
Worm   444 NYFNDATKDMVELMQP-------FKEASHSSDFKYYFGSGVMANFTPTD--EEMEVMDMSGTLMA 499

  Fly   511 TFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQVECVTQVEKDGLKVWN-RLYSDL 567
            .|.:.|||| .::|..||.|.:...|    |:..:::..|....|..:... |:|.|:
Worm   500 NFVKYGDPN-GKSGTKPWKPYTILKP----NMYYKIDYPTCEMSDNFQNGRLRIYDDI 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	146/542 (27%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	73/207 (35%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	149/560 (27%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	49/112 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157274
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750