Protein Alignment alpha-Est6 and cest-16

DIOPT Version :10

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_741812.2
• Gene: cest-16 / 180905
• WormBaseID: WBGene00020330
• Length: 697
• Species: Caenorhabditis elegans
• Alignment Length: 637
• Identity: 160/637 - (25%)
• Similarity: 263/637 - (41%)
• Gaps: 152/637 - (23%)

  Fly    40 SKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIPL 104
            |:.|.:..|.|:| .:..|.|.....|.|:|:|:||:|:.||........|:.||.|.:..|..|
 Worm    23 SRSVWVEQGLVRG-NIYNIDGKHIQIFRGVPYAEPPIGELRFKPPVKKTRWHQELPAVEYGPPCL 86

  Fly   105 Q--------------MDRRSGKVVGSEDCLYLNVYTKHFNESE-PPLPVMVYIYGGAFRTGGAVK 154
            |              |||:      |||||||||::.:..:.| ...|::|:|:||:|..|.|
 Worm    87 QFMDFHKNDKFAKTNMDRQ------SEDCLYLNVFSPYDTDDESKTYPILVWIHGGSFLAGSA-- 143

  Fly   155 SKYGPDY------LMSRDVVYVLFNYRLCSLGFLSMPSG-KLDVPGNAGLHDQLLALQWVSQHIR 212
             ..|.|.      ::|:.:.:|..||||..|||::..:| ||:  ||.|:.|.::||||:..:|:
 Worm   144 -DTGIDMEVIAANIVSKGIAFVSINYRLGPLGFMNYQNGDKLE--GNFGIWDMVMALQWIQSNIK 205

  Fly   213 NFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSA 277
            .|||||..:|:.|||||.|:...:...|:..||.|:||:||||.::.|.....|.
 Worm   206 QFNGDPTKVTVMGESAGGAASSLLALSPKTSGLLHQAIIMSGSSMAGWAIHRHSQ---------- 260

  Fly   278 GYEGPAEEVPIL-------EFLRNVNAEKLIGHDF--------------------------ISPR 309
                ||..|..|       :::...:.::::|.::                          ::..
 Worm   261 ----PAYSVDNLVAYFRCEKWINEDDTKEVVGDEYQHLTHSVIRSALCNYQNVKINCLTDDMTQM 321

  Fly   310 DR--C----FGFLNPF-------------APVVGGLVAAPFQQLMKEAWSCEVPLLLGGTSFE-- 353
            |:  |    ..|.:|.             ..|.|.||.:....|::.  :..:|::.|....|
 Worm   322 DKMNCLRKELNFSSPLFRKALAAELGVSKMVVDGDLVPSSGVSLVRN--NARIPIMTGVARKEWG 384

  Fly   354 --GLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADV-----LVKYHYGPRG-- 409
              ..::|...|.| |.....::.:...::.:..:::.|.:..|:...:     :|:|...|..
 Worm   385 HKKAMFYNMHQRD-GLKRSDVEEQVYRIIDNSFHETASEKLANSTVQLIANATIVRYLETPNNEF 448

  Fly   410 ITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDF--DSPKLNLMRN--QLCG--- 467
            |....:..:..|.|...|.....|.|.:.:... .|.|||.||:  .||.|...|.  .|.|
 Worm   449 IADQVVGALQKLESDIEFVAPCEREVAAYVDKG-VPVYLYSFDYVPKSPILESERKIYSLFGTKP 512

  Fly   468 ---------DDIKRGVCHADDLGYIFHKQAQAK---QPLDSPEFLTIQRMVGILTTFARTGDPNC 520
                     :.:::...|..|..:||.|...:.   .|....|....:.:..:||.|.:.|||:.
 Worm   513 VEMKRTEKSEILEKAAFHGLDHAFIFSKGYSSNFEISPYTKREETMSKILCTMLTNFVKNGDPST 577

  Fly   521 -----PETGPDPWMPVSTKSPFKALNIGQ-----------QVECVTQ-VEKD 555
                 |....:....||...|.|.|. |:           :.|.:|: |.||
 Worm   578 TRFSWPIFSGNSSQYVSLDVPLKLLE-GEIHFPDAQFWNTEAELITRYVSKD 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	151/604 (25%)
cest-16	NP_741812.2	alpha/beta hydrolases	23..608	CDD:473884	155/615 (25%)