DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and cest-26

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001368609.1	Gene:	cest-26 / 180715	WormBaseID:	WBGene00017478	Length:	585	Species:	Caenorhabditis elegans

Alignment Length:	598	Identity:	170/598 - (28%)
Similarity:	246/598 - (41%)	Gaps:	134/598 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIPL 104
            ||.|:...|.|:|.|:......|...|.||||||.|:|..||...:..:.|:......:..|...
Worm    41 SKQVRTRNGLVEGFRIKIDDDREVDMFLGIPFAKAPVGDLRFKNPEHTEDWDGVKKCVRFGPRAP 105

  Fly   105 QMD---RRSGKVVG-SEDCLYLNVYTKHFNESEPP---LPVMVYIYGGAFRTGGAVKSKYGPD-- 160
            |.|   .|....|| |||||||||::..:...|..   .|||||::||.|....||  |||.:
Worm   106 QADFFWERFTLGVGKSEDCLYLNVFSPTWKAEEVSNGLHPVMVYVHGGGFLIDSAV--KYGDEGI 168

  Fly   161 --YLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITL 223
              ||....||.|...|||..|||.|  :|....|||.||.|..:|||||..::..|.|||:.:|:
Worm   169 AKYLCRHGVVVVTIQYRLGLLGFFS--TGDQVCPGNLGLWDMTMALQWVRDNVHAFGGDPRKVTV 231

  Fly   224 FGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPW--------VNAPDSDGIFCRL------- 273
            ||:|||..||..:...|.::.|||:.:.|:|:....|        |||       ||.
Worm   232 FGQSAGGVSVDLLSLSPHSRDLFHQVVPMAGNGECEWSTVGKNRLVNA-------CREFAYRKCW 289

  Fly   274 -ATSAGYEGPAEEVPILEFLR---------------NVNAEKLIGHDFISPRDRCFGFLNPFAPV 322
             ...|..|..:|.  :|||||               .|:..| ||.|              .|||
Worm   290 DEKQARDENASES--MLEFLRTRKEREFEKRLLTRKGVDVSK-IGLD--------------LAPV 337

  Fly   323 VGG----LVAAPFQQLMKEAWSCEVP---LLLGGTSFEGLVYYP-----FCQLDNGYMLELL--- 372
            :|.    .:....::|.|||     |   :::|....|||::..     |.:.....:|.||
Worm   338 IGSKPSDFLPKSIEELRKEA-----PKKNIMVGTCEHEGLLFASLGPSNFDEKGIDKLLALLITE 397

  Fly   373 -KHEPAMVLPHELYQ------SMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHG 430
             .||....|..|..:      |...:::..||          ||        .:.|:|.....:|
Worm   398 ENHEDFEALREEAKKMYLKKLSDDEDDKEVAA----------RG--------YIQLYSDLFVNNG 444

  Fly   431 IHRVVLSRLSHAQAPTYLYRFDFDSPK----LNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAK 491
            .:... .:::......::|.||:.:|:    |:|...       .|...|..:|.|||.......
Worm   445 TYNYA-EKMTKLGNKVFMYSFDYCNPRSFGILSLRAP-------FRAATHCTELAYIFGVSIVFN 501

  Fly   492 QPLDSPEFLTIQRMVGILTTFARTGDPNC---PETGPD-PWMPVSTKSP--FKALNIGQQVECVT 550
            ...:..:...:..|..:.|.||:.|:||.   ..|..| .|.|.|.:.|  |.|:| .::.|..|
Worm   502 YRYNESDRAMLDLMTKMWTNFAKYGNPNGQYEDSTVFDFKWEPTSKEEPTNFLAIN-EKKCEMQT 565

  Fly   551 QVEKDGLKVWNRL 563
            ..:.:..:.|.::
Worm   566 VYQDNRAEFWKKI 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	163/565 (29%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	78/229 (34%)
cest-26	NP_001368609.1	COesterase	40..575	CDD:395084	169/593 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820