Protein Alignment alpha-Est6 and cest-2.3

DIOPT Version :10

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_506510.2
• Gene: cest-2.3 / 179918
• WormBaseID: WBGene00013873
• Length: 665
• Species: Caenorhabditis elegans
• Alignment Length: 571
• Identity: 135/571 - (23%)
• Similarity: 214/571 - (37%)
• Gaps: 187/571 - (32%)

  Fly    43 VKLSVGSVKGRRLSGIY---GDEFYS-FEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIP 103
            ::||.|:::|:.|:..|   |::..: |.|||:.:||:|:.||...:|...|...|:.:..:|..
 Worm    20 IQLSTGTIEGKILNATYSPFGNQTATVFLGIPYVEPPIGELRFRKPRLLKSWEGVLETKDYKPAC 84

  Fly   104 LQMDRRSGK--VVG--SEDCLYLNVYTKHFNESEPPLPVMVYIYGGAF--RTGGAVKSKYGPDYL 162
            :...|::.|  .||  ||||||.||:|..:........||:.::||..  .:|.|.|    |:..
 Worm    85 MSYWRKTFKNGFVGEISEDCLYANVFTNQYCLQNKNCSVMIVVHGGRLVCESGSAFK----PEIF 145

  Fly   163 MS------RDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNI 221
            ::      |::|.|.|||||...||........|.  |..::|.|.|::||.:.|..|.|:...|
 Worm   146 INNFVGQDRNIVVVTFNYRLGVFGFGVFNGETGDT--NVAMYDMLEAVKWVRKEIDQFGGNKDRI 208

  Fly   222 TLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEG---PA 283
            |:.|.||||..:........:|||.|:.|:||         ||..|     ::.||.::|   .|
 Worm   209 TMAGHSAGAGLIVDFTSSTLSKGLLHQQIVMS---------APLQD-----ISKSANFKGMTIVA 259

  Fly   284 EEVPIL--EF----------------LRNVNAEKLIGHD----------FISPR----------D 310
            :.|..:  |:                |:|.:|:.|:...          |.|||          |
 Worm   260 QNVGCIPKEYGFRKLSKTQINKTYLCLQNKSAQDLLHAQLSMQQNSTFYFGSPRVDGDFITDYPD 324

  Fly   311 RCFGF-----LNPFAPVVGG------LVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLD 364
            ..|.|     :|.|.....|      .:..|....:||
 Worm   325 NLFNFNTIYPINTFIGTTTGELRDSLYITDPKNDRIKE--------------------------- 362

  Fly   365 NGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPRGITK------SNITQILDLFS 423
                 :|||:....| .:||::.                   |...||      .|.|....|..
 Worm   363 -----QLLKNMCEHV-GYELFEK-------------------PEEFTKKCGNYYKNGTDAQFLSD 402

  Fly   424 YKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQA 488
            ...|:.|..:|..:. ..|.:..::|.:|:                  :|.      |..|||..
 Worm   403 DMEFYSGAIKVANAH-KRANSKVFMYSYDY------------------KGA------GTAFHKYL 442

  Fly   489 QAKQPLDSPEFL---------------TIQRMV-GILTTFARTGDPNCPET 523
            :|..|..|.:.:               .|:|:. |:|..|....||:..:|
 Worm   443 EAPSPHHSEDLIYTFGTSRGPFVAKDYVIERIYSGMLANFINFEDPSPSKT 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	135/571 (24%)
cest-2.3	NP_506510.2	alpha/beta hydrolases	17..532	CDD:473884	135/571 (24%)