Protein Alignment alpha-Est6 and cest-2.2

DIOPT Version :10

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 143/574 - (24%)
• Similarity: 225/574 - (39%)
• Gaps: 155/574 - (27%)

  Fly    16 FRFLILRCCPGFKRFSCQSAGDADSKVVKLS--VGSVKGRRLSGIY---GDEF-YSFEGIPFAKP 74
            |||.||...          ..:..|..||||  .|:::||.|:..|   |::. ..|.|:|:.:|
 Worm     3 FRFFILWAI----------LQNVRSTKVKLSSRTGTIEGRTLTASYSPLGNQTGIVFFGVPYVEP 57

  Fly    75 PLGKARFVASQLADPWNSELDARQERPIPLQMDRRSGK--VVG--SEDCLYLNVYTKHFNESEPP 135
            |:|..||...:...||:..|:|::.:...:...:::.|  |.|  ||||||.||:|..:......
 Worm    58 PVGNLRFRKPRPPKPWDGVLEAKEYKAACMSDQKKTYKNGVGGPVSEDCLYANVFTNQYCLEHKN 122

  Fly   136 LPVMVYIYGGAFRTGGAVKSKYGPDYLMS------RDVVYVLFNYRLCSLGFLSMPSGKLDVPGN 194
            ..||:.|:||.|....|  |.|.|:.:::      |::|.|.|||||...| |.|.:|. :...|
 Worm   123 CSVMLTIHGGRFVIESA--SAYDPEIIINNFVGQGRNIVVVTFNYRLGLFG-LGMLNGD-NQDTN 183

  Fly   195 AGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSM--L 257
            .||:|.|..::|..:.|:||.||...||:.|.||||.........|.:|||.|:.|:||.||  |
 Worm   184 FGLYDILEVVRWTRKEIKNFGGDKDRITMQGHSAGAVFTAAFSTSPLSKGLIHQQIIMSASMSNL 248

  Fly   258 SPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFAPV 322
            |...|..:       |...|...|...:......|.||..||..         .|
 Worm   249 SKKSNVKE-------LTVVARIVGCLPDEHGFPKLSNVEVEKAY---------TC---------- 287

  Fly   323 VGGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQS 387
               |.:...||::    ..::.:|...|.:.|..:     :|..|.::         .|..||.:
 Worm   288 ---LRSKSAQQIL----DAQLYMLRNTTYYIGQGH-----IDGIYQVD---------YPDNLYAT 331

  Fly   388 MSVEERN-----TAADVL-VKYHYGPRGITKSNI--TQILDLFSYKL------------------ 426
            .|:...|     |.|::: .:|...|:...|..|  ..:.:...|:|
 Worm   332 NSIYPINTMIGTTTAELMDSRYIVDPKNTGKKEILLQNLCEHIGYELYKEPEEFSQKCRNFYKNG 396

  Fly   427 -----------FWHGIHRVVLSRLSHAQAPT--YLYRFDFD-------------SPKLNLMRNQL 465
                       |::|  .:.|:.: |:...|  ::|.||:.             |||
 Worm   397 EDAKSLGDDMEFYYG--AIQLANV-HSSKDTNVFVYSFDYKEAGNAYKKYDKSLSPK-------- 450

  Fly   466 CGDDIKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPN 519
                      |.:|..|.|   ...:....:.:::......|:...|...|||:
 Worm   451 ----------HGEDFAYAF---GTNRGNFSTKDYVIEYIYSGMFADFVNFGDPS 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	138/551 (25%)
cest-2.2	NP_001256567.1	alpha/beta hydrolases	25..534	CDD:473884	133/542 (25%)