DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and cest-17

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_505114.1	Gene:	cest-17 / 179198	WormBaseID:	WBGene00019477	Length:	571	Species:	Caenorhabditis elegans

Alignment Length:	561	Identity:	155/561 - (27%)
Similarity:	241/561 - (42%)	Gaps:	101/561 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 SGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPW-NSELDARQERP--IPLQMDRRSGKVVGSE 117
            |.:.|.:::.|.||.:..||....||...:..:.| :...||...|.  ||........:|..||
Worm    38 STVTGSKYHVFLGIRYGNPPDHIYRFQKPEPVEKWPHINHDATHFRASCIPSLRSELEEQVNYSE 102

  Fly   118 DCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKY--GPDYLMSRDVVYVLFNYRLCSLG 180
            |||:||:.|.. :..|..|||:|:|:||.|:.|......|  ..|..:|:|:::|...|||..||
Worm   103 DCLFLNIVTPP-DAKEKKLPVLVFIHGGGFQFGDTSMIGYQKAADNFVSKDIIFVSIQYRLGPLG 166

  Fly   181 FLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGL 245
            |.:  :|..::|||.||.||.||||::.:.:.:|.|||..|||.|.|||||||..::..|.:..|
Worm   167 FFT--TGDSEIPGNMGLWDQTLALQFLHEVLPDFGGDPDRITLAGHSAGAASVSALLYSPHSDHL 229

  Fly   246 FHKAIMMSGSMLSPW---VNAPDSDGIFCRLATSAGYEGPAE---------EVPILEFLRNVNAE 298
            |.:||.:|||:.|..   .|..|...   :||.:||.  |.|         |:..::.|  ::|.
Worm   230 FSQAIQLSGSIFSESNLDRNVVDDSR---KLAKAAGC--PQEDSKELRDCIEIRTVDEL--LDAM 287

  Fly   299 KLIGHDFISPRDRCFG--FLNPFAPVVGGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFC 361
            :.||.....||.:.|.  |...|.|.       ..:::.::|..        ..:.:|||
Worm   288 ESIGELLPGPRTKKFHPYFDKDFFPY-------DIEKMSRKAPK--------KRTMQGLV----- 332

  Fly   362 QLDNG----YMLELLKHEPAMVLPHELYQSMSVEERNTAAD-----VLVKYHYGPRGITKSNITQ 417
            .|::|    |.::|.|   .:.:|.|   |.|...::...|     |.|:..:|......|.:.:
Worm   333 SLESGLSVLYPVKLAK---LLGVPKE---SWSTYSKDNLVDFIRSQVAVEQEFGTASARFSGLVE 391

  Fly   418 ---------------------ILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLM 461
                                 :|....|.:  ..:|.|.| :|.|.. .||||..|:||......
Worm   392 EFYLSGPMTGNSSFYLNAFANLLSDLQYNI--PTLHEVEL-KLQHGW-DTYLYIIDYDSETTKDP 452

  Fly   462 RNQLCGDDIKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPD 526
            .:.:      :|..||.:|.|:|:.......|.:..:.......|..:..|..||.|:   |...
Worm   453 THPI------KGPFHASELRYLFNFNGMDTIPFNDKDKKFENYFVNAIVNFINTGTPS---TKAL 508

  Fly   527 PWMPVSTKSPFKALNIGQQVECVTQVEKDGLKVWNRLYSDL 567
            .|..||...||..|.:..:....|...::..::|.   ||:
Worm   509 LWPAVSKSQPFANLLLNDKPSVQTSFRQEAYELWQ---SDI 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	148/526 (28%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	76/207 (37%)
cest-17	NP_505114.1	COesterase	20..542	CDD:278561	152/552 (28%)
cest-17	NP_505114.1	Aes	<109..>225	CDD:223730	49/118 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820