DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and cest-34

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001360105.1	Gene:	cest-34 / 179057	WormBaseID:	WBGene00019652	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	146/519 - (28%)
Similarity:	228/519 - (43%)	Gaps:	68/519 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VVKLSVGSVKGRRLSGIYGD-EFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERP--IP 103
            |:..|.|.|.|....  :|| |.:.:.|:|:||||.|:.||.....||.|....|..:..|  .|
Worm    16 VLNTSCGPVLGNLYR--HGDKEVHGYLGMPYAKPPTGEMRFAKPVPADDWTETRDCTKYGPRCPP 78

  Fly   104 LQMDRRSGKVVGSED-----CLYLNVYTKHFNESE--PPLPVMVYIYGGAFRTGGAVKSKYGPDY 161
            .......|..|..::     .|.:||:...:..||  ...|||||::||.|...   .|:...||
Worm    79 SGQGLEKGMFVNPDEPDEANGLSVNVFVPGWESSEYKNARPVMVYVHGGGFEIS---SSREFCDY 140

  Fly   162 LMS-----RDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNI 221
            .:|     :||:.|..||||..|||.:  :|....|||.||.||.||||||.:||.:|.|||.|:
Worm   141 SISSTLPMKDVILVTMNYRLGILGFFT--TGDEVCPGNFGLWDQTLALQWVQKHIASFGGDPNNV 203

  Fly   222 TLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWV--NAPDSDGIFCRLATSAGYEGPAE 284
            ||||:|||.|.|..:...|.::.||.|.:.||||.:..:.  .|.:...:|..:....|:.|...
Worm   204 TLFGQSAGGACVDLLTLSPHSRDLFQKVVPMSGSAMCEFAMRTAENEAHVFDDILARLGFTGSGS 268

  Fly   285 EVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFAPVVGGLVAAPFQQLMKEAWSCEVPLLLGG 349
            : ..|||:|::..:|:.|....:.:..  ||::......|.....|..:|.|:| |..: |:.|.
Worm   269 K-ERLEFMRSLPCDKITGKTGYTYKQS--GFMSLCPNYDGDFFPKPLDELRKDA-SKRI-LMTGI 328

  Fly   350 TSFEGLVY-----YPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPRG 409
            ...|||::     .|:....:...|::          .|.|:...|::.......:.:|:  .:.
Worm   329 VGNEGLLFAFDRNTPYKDYTDLLRLKI----------EEDYKEDVVDDVEGIRKEIFEYY--TKN 381

  Fly   410 ITKSNITQIL----DLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDI 470
            |::.:...|:    :.....:|..|:.....:...|.. ..:||.||:.:|.         |...
Worm   382 ISEGDEEAIMRKAAEFVGDSIFHTGVRATAQNAAEHGD-EVWLYNFDYCNPD---------GFAP 436

  Fly   471 KRGV------CHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPDPW 528
            .:|.      .|..:|.|:|.....:|......|...:.:...:...||:.|:||  |||...|
Worm   437 LKGYLPYIEPTHGMELRYLFGDGIISKFEPTEEELKMLDKFTTMFANFAKYGNPN--ETGSSAW 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	146/519 (28%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	73/200 (37%)
cest-34	NP_001360105.1	COesterase	15..530	CDD:365897	146/519 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14726
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810