DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and cest-33

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_504621.1	Gene:	cest-33 / 179020	WormBaseID:	WBGene00017431	Length:	554	Species:	Caenorhabditis elegans

Alignment Length:	583	Identity:	155/583 - (26%)
Similarity:	239/583 - (40%)	Gaps:	102/583 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KVVKLSVGSVKGRRLSGIYGDE---FYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPI 102
            :.:|.|.|.|:|    .||..:   ...:.|||:||||:|:.||......|.|....|..:..|.
Worm    15 EALKASCGPVRG----NIYKHDDVIVDGYLGIPYAKPPVGELRFKKPVTVDVWTEIKDCYKYGPA 75

  Fly   103 PLQ---MDRRSGKVVGSED---CLYLNVYTKHFNESE--PPLPVMVYIYGG-----------AFR 148
            .:|   .::.:|....:.:   ||.|||:|.....||  ...||||||:||           |:.
Worm    76 CVQTGGFEQIAGPRTPTPEEAGCLTLNVFTPRNASSEFKNGRPVMVYIHGGGYELCASSDFCAYS 140

  Fly   149 TGGAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRN 213
            ..|.:..|         |||.|..||||...|||:  :|....|||.||.||.|||:||.:||.:
Worm   141 LSGTLPLK---------DVVVVSINYRLGVFGFLT--TGDNVCPGNFGLWDQTLALKWVQKHISS 194

  Fly   214 FNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPW-VNAPDSDG-IFCRLATS 276
            |.|||..:|:||:|||.||...:...|.::.||.:.|.:||:....: :.|.::.. ||...|..
Worm   195 FGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRASENQAKIFREFAEF 259

  Fly   277 AGYEGP---------AEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFAPVVGGLVAAPFQ 332
            .|:.|.         .|:.|  |.|.||...|    ..||      |||.....:.|.....|..
Worm   260 HGFSGRDSSALFKWYQEQSP--ETLSNVKGYK----KSIS------GFLTFIPNLDGDFFPKPLD 312

  Fly   333 QLMKEAWSCEVPLLLGGTSFEGLVYY----PFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEER 393
            :|.|||  .:..::.|.|.:|||:..    .|...|.|..|          :|..:|....|..
Worm   313 ELRKEA--PKKQMMTGVTEYEGLMLASMNPAFSPADVGLTL----------MPQGIYGKDVVSN- 364

  Fly   394 NTAADVLVKYHYGP--RGITKSN----ITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFD 452
               .|.:.|..|..  .|:.||:    ..::.:....:.|..|:.:...:...|.. ..|.|.|:
Worm   365 ---PDEIQKIFYEKYVEGVDKSDELAMRKKLCEALGDEFFNVGVIQAAKNAAKHGN-EVYFYTFE 425

  Fly   453 FDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGD 517
            :.:|....|.:.:.  ..|..| |..:|.|:..:...:|......:...::....:.:.||:.|:
Worm   426 YVNPDSFGMWDGMM--PFKAAV-HCTELRYLLGEGVYSKFEPTEEDRKVMETTTTLFSNFAKYGN 487

  Fly   518 PNCPETGPDPWMPVSTKSPFKALNIGQ------------QVECVTQVEKDGLKVWNRLYSDLK 568
            ||......:.|...|...|.:...|..            :::.:.:::.|..|....:|...|
Worm   488 PNGKGATAEIWEKYSLNRPERHYRISYPKCEMRDVYHEGRIQFLEKIDGDSDKYQELVYGKKK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	149/535 (28%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	74/215 (34%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	151/551 (27%)
cest-33	NP_504621.1	Aes	<103..>224	CDD:223730	54/131 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810