DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and cest-12

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_499576.4	Gene:	cest-12 / 176642	WormBaseID:	WBGene00013540	Length:	850	Species:	Caenorhabditis elegans

Alignment Length:	232	Identity:	81/232 - (34%)
Similarity:	122/232 - (52%)	Gaps:	15/232 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VKLSVGSVKGRRL------SGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSEL-DARQER 100
            |..|.|||:||::      |.:|..:..:|.|||:.:.|:|..|....|..:.:|:.| ||...|
Worm    37 VSCSQGSVQGRQVNLGNDQSQLYSGQANAFTGIPYCQAPVGNLRLQPPQPLNQFNTTLHDATYFR 101

  Fly   101 PIPLQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYG-GAFRTGGAVKS--KYGPDYL 162
            |...|:: ..|..  :||||||||||.....:...|.|:|.|.| ..|..||..::  |.....|
Worm   102 PKCPQLN-AGGPT--NEDCLYLNVYTPQAGNTNANLSVLVLIDGSNGFSNGGCDQNQEKGIISNL 163

  Fly   163 MSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGES 227
            :.|.:|.|...||:.:|||.:..:.  .|..|.|:.||:.|::|:...|.||.|:|..||:.|:.
Worm   164 VQRQIVVVTMQYRIGALGFFTTYTN--SVQSNLGMLDQVQAMRWIKTEIVNFGGNPNQITVAGQD 226

  Fly   228 AGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAP 264
            .||.:|......|.::.||::||:.|||:.|.:...|
Worm   227 DGACAVSAHCLSPMSQNLFNQAIVQSGSVYSCYNPTP 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	81/232 (35%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	46/135 (34%)
cest-12	NP_499576.4	Abhydrolase	37..>400	CDD:389770	81/232 (35%)
cest-12	NP_499576.4	Abhydrolase	<678..774	CDD:389770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810